| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EN1 | NDE1 | ENSP00000295206 | ENSP00000345892 | engrailed homeobox 1 | nudE nuclear distribution E homolog 1 (A. nidulans); Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative [...] | 0.748 |
| EN1 | PHB2 | ENSP00000295206 | ENSP00000441875 | engrailed homeobox 1 | prohibitin 2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging | 0.580 |
| EN1 | RAET1E | ENSP00000295206 | ENSP00000349709 | engrailed homeobox 1 | retinoic acid early transcript 1E; Ligand for the NKG2D receptor. Delivers activating signals to NK cells and promotes tumor immune surveillance by inducing the expansion of anti-tumor cytotoxic lymphocytes | 0.501 |
| ENSG00000255819 | HCST | ENSP00000455951 | ENSP00000246551 | NKG2-D type II integral membrane protein | hematopoietic cell signal transducer; Transmembrane adapter protein which associates with NKG2D to form an activation receptor NKG2D-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with NKG2D-DAP10 trigg [...] | 0.564 |
| ENSG00000255819 | KLRK1 | ENSP00000455951 | ENSP00000240618 | NKG2-D type II integral membrane protein | killer cell lectin-like receptor subfamily K, member 1; Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes | 0.576 |
| ENSG00000255819 | RAET1E | ENSP00000455951 | ENSP00000349709 | NKG2-D type II integral membrane protein | retinoic acid early transcript 1E; Ligand for the NKG2D receptor. Delivers activating signals to NK cells and promotes tumor immune surveillance by inducing the expansion of anti-tumor cytotoxic lymphocytes | 0.576 |
| ENSG00000255819 | ULBP3 | ENSP00000455951 | ENSP00000356308 | NKG2-D type II integral membrane protein | UL16 binding protein 3; Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP2. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. Has lower affinity for NKG2D compared to ULBP1 and ULBP2 and induces weaker signaling responses than does ULBP2 or ULBP1 | 0.576 |
| HCST | ENSG00000255819 | ENSP00000246551 | ENSP00000455951 | hematopoietic cell signal transducer; Transmembrane adapter protein which associates with NKG2D to form an activation receptor NKG2D-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with NKG2D-DAP10 trigg [...] | NKG2-D type II integral membrane protein | 0.564 |
| HCST | KLRK1 | ENSP00000246551 | ENSP00000240618 | hematopoietic cell signal transducer; Transmembrane adapter protein which associates with NKG2D to form an activation receptor NKG2D-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with NKG2D-DAP10 trigg [...] | killer cell lectin-like receptor subfamily K, member 1; Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes | 0.993 |
| HCST | RAET1E | ENSP00000246551 | ENSP00000349709 | hematopoietic cell signal transducer; Transmembrane adapter protein which associates with NKG2D to form an activation receptor NKG2D-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with NKG2D-DAP10 trigg [...] | retinoic acid early transcript 1E; Ligand for the NKG2D receptor. Delivers activating signals to NK cells and promotes tumor immune surveillance by inducing the expansion of anti-tumor cytotoxic lymphocytes | 0.939 |
| HCST | ULBP1 | ENSP00000246551 | ENSP00000229708 | hematopoietic cell signal transducer; Transmembrane adapter protein which associates with NKG2D to form an activation receptor NKG2D-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with NKG2D-DAP10 trigg [...] | UL16 binding protein 1; Ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. [...] | 0.972 |
| HCST | ULBP3 | ENSP00000246551 | ENSP00000356308 | hematopoietic cell signal transducer; Transmembrane adapter protein which associates with NKG2D to form an activation receptor NKG2D-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with NKG2D-DAP10 trigg [...] | UL16 binding protein 3; Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP2. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. Has lower affinity for NKG2D compared to ULBP1 and ULBP2 and induces weaker signaling responses than does ULBP2 or ULBP1 | 0.972 |
| KLRC4 | KLRK1 | ENSP00000310216 | ENSP00000240618 | killer cell lectin-like receptor subfamily C, member 4; May play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells | killer cell lectin-like receptor subfamily K, member 1; Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes | 0.418 |
| KLRC4 | RAE1 | ENSP00000310216 | ENSP00000360286 | killer cell lectin-like receptor subfamily C, member 4; May play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells | RAE1 RNA export 1 homolog (S. pombe); Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton | 0.710 |
| KLRC4 | RAET1E | ENSP00000310216 | ENSP00000349709 | killer cell lectin-like receptor subfamily C, member 4; May play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells | retinoic acid early transcript 1E; Ligand for the NKG2D receptor. Delivers activating signals to NK cells and promotes tumor immune surveillance by inducing the expansion of anti-tumor cytotoxic lymphocytes | 0.512 |
| KLRC4 | ULBP1 | ENSP00000310216 | ENSP00000229708 | killer cell lectin-like receptor subfamily C, member 4; May play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells | UL16 binding protein 1; Ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. [...] | 0.738 |
| KLRC4 | ULBP3 | ENSP00000310216 | ENSP00000356308 | killer cell lectin-like receptor subfamily C, member 4; May play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells | UL16 binding protein 3; Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP2. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. Has lower affinity for NKG2D compared to ULBP1 and ULBP2 and induces weaker signaling responses than does ULBP2 or ULBP1 | 0.405 |
| KLRK1 | ENSG00000255819 | ENSP00000240618 | ENSP00000455951 | killer cell lectin-like receptor subfamily K, member 1; Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes | NKG2-D type II integral membrane protein | 0.576 |
| KLRK1 | HCST | ENSP00000240618 | ENSP00000246551 | killer cell lectin-like receptor subfamily K, member 1; Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes | hematopoietic cell signal transducer; Transmembrane adapter protein which associates with NKG2D to form an activation receptor NKG2D-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with NKG2D-DAP10 trigg [...] | 0.993 |
| KLRK1 | KLRC4 | ENSP00000240618 | ENSP00000310216 | killer cell lectin-like receptor subfamily K, member 1; Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes | killer cell lectin-like receptor subfamily C, member 4; May play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells | 0.418 |
Share
