| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| HJURP | NUDT13 | ENSP00000414109 | ENSP00000349874 | Holliday junction recognition protein; Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions | nudix (nucleoside diphosphate linked moiety X)-type motif 13 | 0.472 |
| NUDT10 | NUDT13 | ENSP00000348831 | ENSP00000349874 | nudix (nucleoside diphosphate linked moiety X)-type motif 10; Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate | nudix (nucleoside diphosphate linked moiety X)-type motif 13 | 0.541 |
| NUDT10 | NUDT5 | ENSP00000348831 | ENSP00000419628 | nudix (nucleoside diphosphate linked moiety X)-type motif 10; Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate | nudix (nucleoside diphosphate linked moiety X)-type motif 5; Hydrolyzes with similar activities ADP-ribose ADP- mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA | 0.559 |
| NUDT10 | NUDT7 | ENSP00000348831 | ENSP00000268533 | nudix (nucleoside diphosphate linked moiety X)-type motif 10; Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate | nudix (nucleoside diphosphate linked moiety X)-type motif 7; Coenzyme A diphosphatase which mediates the cleavage of CoA, CoA esters and oxidized CoA with similar efficiencies, yielding 3’,5’-ADP and the corresponding 4’-phosphopantetheine derivative as products. CoA into 3’,5’-ADP and 4’- phosphopantetheine. Has no activity toward NDP-sugars, CDP- alcohols, (deoxy)nucleoside 5’-triphosphates, nucleoside 5’-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5’-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, [...] | 0.483 |
| NUDT10 | NUDT8 | ENSP00000348831 | ENSP00000301490 | nudix (nucleoside diphosphate linked moiety X)-type motif 10; Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate | nudix (nucleoside diphosphate linked moiety X)-type motif 8; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives (By similarity) | 0.483 |
| NUDT11 | NUDT13 | ENSP00000365160 | ENSP00000349874 | nudix (nucleoside diphosphate linked moiety X)-type motif 11; Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate | nudix (nucleoside diphosphate linked moiety X)-type motif 13 | 0.541 |
| NUDT11 | NUDT2 | ENSP00000365160 | ENSP00000338397 | nudix (nucleoside diphosphate linked moiety X)-type motif 11; Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate | nudix (nucleoside diphosphate linked moiety X)-type motif 2; Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis | 0.490 |
| NUDT11 | NUDT5 | ENSP00000365160 | ENSP00000419628 | nudix (nucleoside diphosphate linked moiety X)-type motif 11; Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate | nudix (nucleoside diphosphate linked moiety X)-type motif 5; Hydrolyzes with similar activities ADP-ribose ADP- mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA | 0.671 |
| NUDT11 | NUDT7 | ENSP00000365160 | ENSP00000268533 | nudix (nucleoside diphosphate linked moiety X)-type motif 11; Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate | nudix (nucleoside diphosphate linked moiety X)-type motif 7; Coenzyme A diphosphatase which mediates the cleavage of CoA, CoA esters and oxidized CoA with similar efficiencies, yielding 3’,5’-ADP and the corresponding 4’-phosphopantetheine derivative as products. CoA into 3’,5’-ADP and 4’- phosphopantetheine. Has no activity toward NDP-sugars, CDP- alcohols, (deoxy)nucleoside 5’-triphosphates, nucleoside 5’-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5’-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, [...] | 0.483 |
| NUDT11 | NUDT8 | ENSP00000365160 | ENSP00000301490 | nudix (nucleoside diphosphate linked moiety X)-type motif 11; Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate | nudix (nucleoside diphosphate linked moiety X)-type motif 8; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives (By similarity) | 0.483 |
| NUDT13 | HJURP | ENSP00000349874 | ENSP00000414109 | nudix (nucleoside diphosphate linked moiety X)-type motif 13 | Holliday junction recognition protein; Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions | 0.472 |
| NUDT13 | NUDT10 | ENSP00000349874 | ENSP00000348831 | nudix (nucleoside diphosphate linked moiety X)-type motif 13 | nudix (nucleoside diphosphate linked moiety X)-type motif 10; Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate | 0.541 |
| NUDT13 | NUDT11 | ENSP00000349874 | ENSP00000365160 | nudix (nucleoside diphosphate linked moiety X)-type motif 13 | nudix (nucleoside diphosphate linked moiety X)-type motif 11; Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate | 0.541 |
| NUDT13 | NUDT15 | ENSP00000349874 | ENSP00000258662 | nudix (nucleoside diphosphate linked moiety X)-type motif 13 | nudix (nucleoside diphosphate linked moiety X)-type motif 15; Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro, suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8- oxoguanine) from DNA and the nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A-T to C-G transversions. Its substrate specificity in vivo however remains unclear (By similarity). May have a role in DNA synthesis and cell cycle progression through the interaction with PCNA | 0.489 |
| NUDT13 | NUDT2 | ENSP00000349874 | ENSP00000338397 | nudix (nucleoside diphosphate linked moiety X)-type motif 13 | nudix (nucleoside diphosphate linked moiety X)-type motif 2; Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis | 0.541 |
| NUDT13 | NUDT5 | ENSP00000349874 | ENSP00000419628 | nudix (nucleoside diphosphate linked moiety X)-type motif 13 | nudix (nucleoside diphosphate linked moiety X)-type motif 5; Hydrolyzes with similar activities ADP-ribose ADP- mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA | 0.504 |
| NUDT13 | NUDT7 | ENSP00000349874 | ENSP00000268533 | nudix (nucleoside diphosphate linked moiety X)-type motif 13 | nudix (nucleoside diphosphate linked moiety X)-type motif 7; Coenzyme A diphosphatase which mediates the cleavage of CoA, CoA esters and oxidized CoA with similar efficiencies, yielding 3’,5’-ADP and the corresponding 4’-phosphopantetheine derivative as products. CoA into 3’,5’-ADP and 4’- phosphopantetheine. Has no activity toward NDP-sugars, CDP- alcohols, (deoxy)nucleoside 5’-triphosphates, nucleoside 5’-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5’-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, [...] | 0.489 |
| NUDT13 | NUDT8 | ENSP00000349874 | ENSP00000301490 | nudix (nucleoside diphosphate linked moiety X)-type motif 13 | nudix (nucleoside diphosphate linked moiety X)-type motif 8; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives (By similarity) | 0.489 |
| NUDT15 | NUDT13 | ENSP00000258662 | ENSP00000349874 | nudix (nucleoside diphosphate linked moiety X)-type motif 15; Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro, suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8- oxoguanine) from DNA and the nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A-T to C-G transversions. Its substrate specificity in vivo however remains unclear (By similarity). May have a role in DNA synthesis and cell cycle progression through the interaction with PCNA | nudix (nucleoside diphosphate linked moiety X)-type motif 13 | 0.489 |
| NUDT15 | NUDT2 | ENSP00000258662 | ENSP00000338397 | nudix (nucleoside diphosphate linked moiety X)-type motif 15; Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro, suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8- oxoguanine) from DNA and the nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A-T to C-G transversions. Its substrate specificity in vivo however remains unclear (By similarity). May have a role in DNA synthesis and cell cycle progression through the interaction with PCNA | nudix (nucleoside diphosphate linked moiety X)-type motif 2; Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis | 0.414 |
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