node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADAMTSL4 | DLK2 | ENSP00000271643 | ENSP00000349893 | ADAMTS-like 4; Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis | delta-like 2 homolog (Drosophila); Regulates adipogenesis (By similarity) | 0.699 |
DLG5 | DLK2 | ENSP00000361467 | ENSP00000349893 | discs, large homolog 5 (Drosophila) | delta-like 2 homolog (Drosophila); Regulates adipogenesis (By similarity) | 0.680 |
DLG5 | PRKCI | ENSP00000361467 | ENSP00000295797 | discs, large homolog 5 (Drosophila) | protein kinase C, iota; Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a [...] | 0.611 |
DLG5 | PRKCZ | ENSP00000361467 | ENSP00000367830 | discs, large homolog 5 (Drosophila) | protein kinase C, zeta; Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required [...] | 0.621 |
DLK2 | ADAMTSL4 | ENSP00000349893 | ENSP00000271643 | delta-like 2 homolog (Drosophila); Regulates adipogenesis (By similarity) | ADAMTS-like 4; Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis | 0.699 |
DLK2 | DLG5 | ENSP00000349893 | ENSP00000361467 | delta-like 2 homolog (Drosophila); Regulates adipogenesis (By similarity) | discs, large homolog 5 (Drosophila) | 0.680 |
DLK2 | FSIP2 | ENSP00000349893 | ENSP00000344403 | delta-like 2 homolog (Drosophila); Regulates adipogenesis (By similarity) | fibrous sheath interacting protein 2 | 0.476 |
DLK2 | GFM1 | ENSP00000349893 | ENSP00000419038 | delta-like 2 homolog (Drosophila); Regulates adipogenesis (By similarity) | G elongation factor, mitochondrial 1; Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A- site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of m [...] | 0.502 |
DLK2 | INADL | ENSP00000349893 | ENSP00000360200 | delta-like 2 homolog (Drosophila); Regulates adipogenesis (By similarity) | InaD-like (Drosophila) | 0.655 |
DLK2 | MIB2 | ENSP00000349893 | ENSP00000426103 | delta-like 2 homolog (Drosophila); Regulates adipogenesis (By similarity) | mindbomb E3 ubiquitin protein ligase 2 | 0.608 |
DLK2 | PARD3 | ENSP00000349893 | ENSP00000363921 | delta-like 2 homolog (Drosophila); Regulates adipogenesis (By similarity) | par-3 partitioning defective 3 homolog (C. elegans) | 0.530 |
DLK2 | PDZD2 | ENSP00000349893 | ENSP00000282493 | delta-like 2 homolog (Drosophila); Regulates adipogenesis (By similarity) | PDZ domain containing 2 | 0.655 |
DLK2 | PRKCI | ENSP00000349893 | ENSP00000295797 | delta-like 2 homolog (Drosophila); Regulates adipogenesis (By similarity) | protein kinase C, iota; Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a [...] | 0.518 |
DLK2 | PRKCZ | ENSP00000349893 | ENSP00000367830 | delta-like 2 homolog (Drosophila); Regulates adipogenesis (By similarity) | protein kinase C, zeta; Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required [...] | 0.518 |
FSIP2 | DLK2 | ENSP00000344403 | ENSP00000349893 | fibrous sheath interacting protein 2 | delta-like 2 homolog (Drosophila); Regulates adipogenesis (By similarity) | 0.476 |
GFM1 | DLK2 | ENSP00000419038 | ENSP00000349893 | G elongation factor, mitochondrial 1; Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A- site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of m [...] | delta-like 2 homolog (Drosophila); Regulates adipogenesis (By similarity) | 0.502 |
INADL | DLK2 | ENSP00000360200 | ENSP00000349893 | InaD-like (Drosophila) | delta-like 2 homolog (Drosophila); Regulates adipogenesis (By similarity) | 0.655 |
INADL | PARD3 | ENSP00000360200 | ENSP00000363921 | InaD-like (Drosophila) | par-3 partitioning defective 3 homolog (C. elegans) | 0.753 |
INADL | PRKCI | ENSP00000360200 | ENSP00000295797 | InaD-like (Drosophila) | protein kinase C, iota; Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a [...] | 0.687 |
INADL | PRKCZ | ENSP00000360200 | ENSP00000367830 | InaD-like (Drosophila) | protein kinase C, zeta; Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required [...] | 0.710 |