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MIB2 MIB2 GFM1 GFM1 DLG5 DLG5 DLK2 DLK2 PRKCI PRKCI PRKCZ PRKCZ PARD3 PARD3 ADAMTSL4 ADAMTSL4 PDZD2 PDZD2 FSIP2 FSIP2 INADL INADL
"DLK2" - delta-like 2 homolog in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
DLK2delta-like 2 homolog (Drosophila); Regulates adipogenesis (By similarity) (383 aa)    
Predicted Functional Partners:
ADAMTSL4
ADAMTS-like 4; Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis (1074 aa)
        score_image   score_image   0.699
DLG5
discs, large homolog 5 (Drosophila) (1919 aa)
        score_image   score_image   0.680
INADL
InaD-like (Drosophila) (1801 aa)
        score_image   score_image   0.655
PDZD2
PDZ domain containing 2 (2839 aa)
        score_image   score_image   0.655
MIB2
mindbomb E3 ubiquitin protein ligase 2 (1070 aa)
            score_image   0.608
PARD3
par-3 partitioning defective 3 homolog (C. elegans) (1356 aa)
        score_image   score_image   0.530
PRKCZ
protein kinase C, zeta; Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required [...] (592 aa)
        score_image   score_image   0.518
PRKCI
protein kinase C, iota; Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a [...] (596 aa)
        score_image   score_image   0.518
GFM1
G elongation factor, mitochondrial 1; Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A- site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of m [...] (751 aa)
            score_image   0.502
FSIP2
fibrous sheath interacting protein 2 (6996 aa)
            score_image   0.476
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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