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STRINGSTRING
SEPHS2 SEPHS2 USP34 USP34 ZFYVE19 ZFYVE19 OSGEP OSGEP PUM1 PUM1 LAGE3 LAGE3 UBC UBC TP53RK TP53RK RAB5B RAB5B UBL4A UBL4A TOM1L2 TOM1L2
"LAGE3" - L antigen family, member 3 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LAGE3L antigen family, member 3 (143 aa)    
Predicted Functional Partners:
UBC
ubiquitin C (685 aa)
        score_image       0.925
TP53RK
TP53 regulating kinase; Protein kinase that phosphorylates ’Ser-15’ of p53/TP53 protein and may therefore participate in its activation (253 aa)
        score_image   score_image   0.905
UBL4A
ubiquitin-like 4A; Component of the BAT3 complex, a multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. The complex acts by facilitating TA proteins capture by ASNA1/TRC40- it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins, and transfers them to ASNA1/TRC40 for targeting (157 aa)
      score_image     score_image   0.814
OSGEP
O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) (335 aa)
        score_image   score_image   0.750
USP34
ubiquitin specific peptidase 34 (3546 aa)
        score_image   score_image   0.646
SEPHS2
selenophosphate synthetase 2; Synthesizes selenophosphate from selenide and ATP (448 aa)
        score_image       0.644
PUM1
pumilio homolog 1 (Drosophila); Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3’-UTR of mRNA targets. May be required to support proliferation and self-renewal of stem cells (By similarity) (1188 aa)
        score_image       0.644
TOM1L2
target of myb1-like 2 (chicken); Probable role in protein transport. May regulate growth factor-induced mitogenic signaling (507 aa)
        score_image       0.644
RAB5B
RAB5B, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) (215 aa)
        score_image       0.644
ZFYVE19
zinc finger, FYVE domain containing 19 (471 aa)
        score_image       0.644
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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