Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
KIAA1468 KIAA1468 PTPN13 PTPN13 CD99 CD99 UBC UBC TGDS TGDS SDCCAG3 SDCCAG3 AP1M1 AP1M1 GPSM1 GPSM1 THEMIS2 THEMIS2 SLC9A4 SLC9A4 NKX2-3 NKX2-3
"SDCCAG3" - serologically defined colon cancer antigen 3 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SDCCAG3serologically defined colon cancer antigen 3 (435 aa)    
Predicted Functional Partners:
PTPN13
protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) (2490 aa)
            score_image   0.817
AP1M1
adaptor-related protein complex 1, mu 1 subunit; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules (435 aa)
        score_image       0.749
UBC
ubiquitin C (685 aa)
        score_image       0.725
CD99
CD99 molecule; Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes (By similarity) (185 aa)
        score_image       0.573
NKX2-3
NK2 homeobox 3; Transcription factor (By similarity) (364 aa)
            score_image   0.487
GPSM1
G-protein signaling modulator 1; Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G- protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction (675 aa)
            score_image   0.483
SLC9A4
solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. May play a specialized role in the kidney in rectifying cell volume in response to extreme fluctuations of hyperosmolar-stimulated cell shrinkage. Is relatively amiloride and ethylisopropylamiloride (EIPA) insensitive. Can be activated under conditions of [...] (798 aa)
            score_image   0.483
TGDS
TDP-glucose 4,6-dehydratase (350 aa)
            score_image   0.479
THEMIS2
thymocyte selection associated family member 2 (643 aa)
            score_image   0.472
KIAA1468
KIAA1468 (1216 aa)
            score_image   0.472
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: medium (45%)