node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CPSF7 | ERGIC3 | ENSP00000345412 | ENSP00000349970 | cleavage and polyadenylation specific factor 7, 59kDa; Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3’ processing. Binds to cleavage and polyadenylation RNA substrates | ERGIC and golgi 3; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) | 0.644 |
CPSF7 | UBC | ENSP00000345412 | ENSP00000344818 | cleavage and polyadenylation specific factor 7, 59kDa; Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3’ processing. Binds to cleavage and polyadenylation RNA substrates | ubiquitin C | 0.807 |
ERGIC1 | ERGIC3 | ENSP00000377374 | ENSP00000349970 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1; Possible role in transport between endoplasmic reticulum and Golgi | ERGIC and golgi 3; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) | 0.672 |
ERGIC1 | ERO1L | ENSP00000377374 | ENSP00000379042 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1; Possible role in transport between endoplasmic reticulum and Golgi | ERO1-like (S. cerevisiae); Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of g [...] | 0.627 |
ERGIC1 | ERO1LB | ENSP00000377374 | ENSP00000346635 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1; Possible role in transport between endoplasmic reticulum and Golgi | ERO1-like beta (S. cerevisiae); Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently [...] | 0.710 |
ERGIC1 | SURF4 | ENSP00000377374 | ENSP00000361057 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1; Possible role in transport between endoplasmic reticulum and Golgi | surfeit 4; May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi | 0.891 |
ERGIC1 | UBC | ENSP00000377374 | ENSP00000344818 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1; Possible role in transport between endoplasmic reticulum and Golgi | ubiquitin C | 0.853 |
ERGIC2 | ERGIC3 | ENSP00000353270 | ENSP00000349970 | ERGIC and golgi 2; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) | ERGIC and golgi 3; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) | 0.961 |
ERGIC2 | ERO1L | ENSP00000353270 | ENSP00000379042 | ERGIC and golgi 2; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) | ERO1-like (S. cerevisiae); Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of g [...] | 0.710 |
ERGIC2 | ERO1LB | ENSP00000353270 | ENSP00000346635 | ERGIC and golgi 2; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) | ERO1-like beta (S. cerevisiae); Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently [...] | 0.710 |
ERGIC2 | SURF4 | ENSP00000353270 | ENSP00000361057 | ERGIC and golgi 2; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) | surfeit 4; May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi | 0.764 |
ERGIC2 | UBC | ENSP00000353270 | ENSP00000344818 | ERGIC and golgi 2; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) | ubiquitin C | 0.850 |
ERGIC3 | CPSF7 | ENSP00000349970 | ENSP00000345412 | ERGIC and golgi 3; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) | cleavage and polyadenylation specific factor 7, 59kDa; Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3’ processing. Binds to cleavage and polyadenylation RNA substrates | 0.644 |
ERGIC3 | ERGIC1 | ENSP00000349970 | ENSP00000377374 | ERGIC and golgi 3; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1; Possible role in transport between endoplasmic reticulum and Golgi | 0.672 |
ERGIC3 | ERGIC2 | ENSP00000349970 | ENSP00000353270 | ERGIC and golgi 3; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) | ERGIC and golgi 2; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) | 0.961 |
ERGIC3 | ERO1L | ENSP00000349970 | ENSP00000379042 | ERGIC and golgi 3; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) | ERO1-like (S. cerevisiae); Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of g [...] | 0.758 |
ERGIC3 | ERO1LB | ENSP00000349970 | ENSP00000346635 | ERGIC and golgi 3; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) | ERO1-like beta (S. cerevisiae); Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently [...] | 0.758 |
ERGIC3 | FAM18A | ENSP00000349970 | ENSP00000299866 | ERGIC and golgi 3; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) | family with sequence similarity 18, member A | 0.575 |
ERGIC3 | FAM18B1 | ENSP00000349970 | ENSP00000305654 | ERGIC and golgi 3; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) | family with sequence similarity 18, member B1 | 0.575 |
ERGIC3 | SURF4 | ENSP00000349970 | ENSP00000361057 | ERGIC and golgi 3; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) | surfeit 4; May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi | 0.626 |