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STRINGSTRING
FAM18A FAM18A SURF4 SURF4 ERGIC1 ERGIC1 ERGIC2 ERGIC2 ERGIC3 ERGIC3 ERO1L ERO1L ERO1LB ERO1LB FAM18B1 FAM18B1 UBC UBC UBB UBB CPSF7 CPSF7
"ERGIC3" - ERGIC and golgi 3 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ERGIC3ERGIC and golgi 3; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) (388 aa)    
Predicted Functional Partners:
UBC
ubiquitin C (685 aa)
        score_image       0.973
ERGIC2
ERGIC and golgi 2; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) (377 aa)
      score_image score_image   score_image score_image 0.961
ERO1L
ERO1-like (S. cerevisiae); Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of g [...] (468 aa)
        score_image   score_image   0.758
ERO1LB
ERO1-like beta (S. cerevisiae); Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently [...] (467 aa)
        score_image   score_image   0.758
UBB
ubiquitin B (229 aa)
        score_image   score_image   0.685
ERGIC1
endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1; Possible role in transport between endoplasmic reticulum and Golgi (290 aa)
        score_image   score_image score_image 0.672
CPSF7
cleavage and polyadenylation specific factor 7, 59kDa; Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3’ processing. Binds to cleavage and polyadenylation RNA substrates (514 aa)
        score_image       0.644
SURF4
surfeit 4; May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi (269 aa)
        score_image   score_image   0.626
FAM18B1
family with sequence similarity 18, member B1 (205 aa)
            score_image   0.575
FAM18A
family with sequence similarity 18, member A (213 aa)
            score_image   0.575
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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