C7orf50 protein (Homo sapiens) - STRING network view

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C7orf50

chromosome 7 open reading frame 50 (194 aa)

Predicted Functional Partners:

FTSJ3

0.734

KRR1

0.667

EBNA1BP2

0.660

MKI67IP

0.645

PPP1R26

0.540

DNTTIP2

0.532

ADARB1

0.525

UBC

0.495

DKC1

0.492

TRUB1

0.492

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADARB1	C7orf50	ENSP00000353920	ENSP00000350011	adenosine deaminase, RNA-specific, B1	chromosome 7 open reading frame 50	0.525
ADARB1	EBNA1BP2	ENSP00000353920	ENSP00000407323	adenosine deaminase, RNA-specific, B1	EBNA1 binding protein 2; Required for the processing of the 27S pre-rRNA (By similarity)	0.483
ADARB1	MKI67IP	ENSP00000353920	ENSP00000285814	adenosine deaminase, RNA-specific, B1	MKI67 (FHA domain) interacting nucleolar phosphoprotein	0.481
C7orf50	ADARB1	ENSP00000350011	ENSP00000353920	chromosome 7 open reading frame 50	adenosine deaminase, RNA-specific, B1	0.525
C7orf50	DKC1	ENSP00000350011	ENSP00000358563	chromosome 7 open reading frame 50	dyskeratosis congenita 1, dyskerin; Isoform 1- Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine (’psi’) residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomera [...]	0.492
C7orf50	DNTTIP2	ENSP00000350011	ENSP00000411010	chromosome 7 open reading frame 50	deoxynucleotidyltransferase, terminal, interacting protein 2; Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein	0.532
C7orf50	EBNA1BP2	ENSP00000350011	ENSP00000407323	chromosome 7 open reading frame 50	EBNA1 binding protein 2; Required for the processing of the 27S pre-rRNA (By similarity)	0.660
C7orf50	FTSJ3	ENSP00000350011	ENSP00000396673	chromosome 7 open reading frame 50	FtsJ homolog 3 (E. coli); Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation	0.734
C7orf50	KRR1	ENSP00000350011	ENSP00000229214	chromosome 7 open reading frame 50	KRR1, small subunit (SSU) processome component, homolog (yeast); Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity)	0.667
C7orf50	MKI67IP	ENSP00000350011	ENSP00000285814	chromosome 7 open reading frame 50	MKI67 (FHA domain) interacting nucleolar phosphoprotein	0.645
C7orf50	PPP1R26	ENSP00000350011	ENSP00000349274	chromosome 7 open reading frame 50	protein phosphatase 1, regulatory subunit 26; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. May positively regulate cell proliferation	0.540
C7orf50	TRUB1	ENSP00000350011	ENSP00000298746	chromosome 7 open reading frame 50	TruB pseudouridine (psi) synthase homolog 1 (E. coli); May be responsible for synthesis of pseudouridine from uracil in transfer RNAs (By similarity)	0.492
C7orf50	UBC	ENSP00000350011	ENSP00000344818	chromosome 7 open reading frame 50	ubiquitin C	0.495
DKC1	C7orf50	ENSP00000358563	ENSP00000350011	dyskeratosis congenita 1, dyskerin; Isoform 1- Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine (’psi’) residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomera [...]	chromosome 7 open reading frame 50	0.492
DKC1	DNTTIP2	ENSP00000358563	ENSP00000411010	dyskeratosis congenita 1, dyskerin; Isoform 1- Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine (’psi’) residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomera [...]	deoxynucleotidyltransferase, terminal, interacting protein 2; Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein	0.426
DKC1	EBNA1BP2	ENSP00000358563	ENSP00000407323	dyskeratosis congenita 1, dyskerin; Isoform 1- Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine (’psi’) residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomera [...]	EBNA1 binding protein 2; Required for the processing of the 27S pre-rRNA (By similarity)	0.883
DKC1	FTSJ3	ENSP00000358563	ENSP00000396673	dyskeratosis congenita 1, dyskerin; Isoform 1- Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine (’psi’) residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomera [...]	FtsJ homolog 3 (E. coli); Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation	0.838
DKC1	KRR1	ENSP00000358563	ENSP00000229214	dyskeratosis congenita 1, dyskerin; Isoform 1- Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine (’psi’) residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomera [...]	KRR1, small subunit (SSU) processome component, homolog (yeast); Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity)	0.959
DKC1	MKI67IP	ENSP00000358563	ENSP00000285814	dyskeratosis congenita 1, dyskerin; Isoform 1- Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine (’psi’) residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomera [...]	MKI67 (FHA domain) interacting nucleolar phosphoprotein	0.986
DKC1	TRUB1	ENSP00000358563	ENSP00000298746	dyskeratosis congenita 1, dyskerin; Isoform 1- Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine (’psi’) residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomera [...]	TruB pseudouridine (psi) synthase homolog 1 (E. coli); May be responsible for synthesis of pseudouridine from uracil in transfer RNAs (By similarity)	0.412

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