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PRKG1 PRKG1 CD22 CD22 PRKG2 PRKG2 NOS1 NOS1 ATP2B4 ATP2B4 PRKACG PRKACG UBC UBC PRKACA PRKACA PRKACB PRKACB DLG1 DLG1 CALM2 CALM2
"ATP2B4" - ATPase, Ca++ transporting, plasma membrane 4 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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second shell of interactors
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Known Interactions
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experiment edge
experimentally determined
Predicted Interactions
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fusion edge
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textmining
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protein homology
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ATP2B4ATPase, Ca++ transporting, plasma membrane 4; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (1205 aa)    
Predicted Functional Partners:
CALM2
calmodulin 2 (phosphorylase kinase, delta) (149 aa)
      score_image score_image   score_image   0.963
UBC
ubiquitin C (685 aa)
        score_image   score_image   0.928
NOS1
nitric oxide synthase 1 (neuronal); Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR (1468 aa)
        score_image   score_image   0.917
DLG1
discs, large homolog 1 (Drosophila) (926 aa)
        score_image   score_image   0.864
CD22
CD22 molecule (847 aa)
        score_image   score_image   0.849
PRKACB
protein kinase, cAMP-dependent, catalytic, beta (398 aa)
          score_image score_image   0.801
PRKACG
protein kinase, cAMP-dependent, catalytic, gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus (351 aa)
          score_image     0.800
PRKG1
protein kinase, cGMP-dependent, type I; Serine/threonine protein kinase that acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of t [...] (686 aa)
          score_image     0.800
PRKACA
protein kinase, cAMP-dependent, catalytic, alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, TRPC1 and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in th [...] (351 aa)
          score_image     0.800
PRKG2
protein kinase, cGMP-dependent, type II (762 aa)
          score_image     0.800
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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