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ARR3 ARR3 RDH13 RDH13 ISX ISX RBP4 RBP4 BCO2 BCO2 ARRB1 ARRB1 SDR9C7 SDR9C7 ARRB2 ARRB2 ALDH3A2 ALDH3A2 STX17 STX17 STARD3 STARD3
"BCO2" - beta-carotene oxygenase 2 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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second shell of interactors
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Known Interactions
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experimentally determined
Predicted Interactions
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fusion edge
gene fusions
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gene co-occurrence
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protein homology
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Score
BCO2beta-carotene oxygenase 2; Asymmetrically cleaves beta-carotene at the 9’,10’ double bond resulting in the formation of beta-apo-10’-carotenal and beta-ionone. Besides beta-carotene, lycopene is also oxidatively cleaved. The apocarotenals formed by this enzyme may be the precursors for the biosynthesis of retinoic acid or exert unknown physiological effects (579 aa)    
Predicted Functional Partners:
ISX
intestine-specific homeobox; Transcription factor that regulates gene expression in intestine. May participate in vitamin A metabolism most likely by regulating BCMO1 expression in the intestine (By similarity) (245 aa)
            score_image   0.665
ALDH3A2
aldehyde dehydrogenase 3 family, member A2; Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid (508 aa)
            score_image   0.559
RDH13
retinol dehydrogenase 13 (all-trans/9-cis) (331 aa)
  score_image         score_image   0.515
STX17
syntaxin 17; SNAREs, Soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane. May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediat [...] (302 aa)
            score_image   0.515
RBP4
retinol binding protein 4, plasma; Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli (201 aa)
            score_image   0.480
SDR9C7
short chain dehydrogenase/reductase family 9C, member 7; Displays weak conversion of all-trans-retinal to all- trans-retinol in the presence of NADH. Has apparently no steroid dehydrogenase activity (313 aa)
            score_image   0.477
STARD3
StAR-related lipid transfer (START) domain containing 3; Binds and transports cholesterol. Promotes steroidogenesis in placenta and brain (445 aa)
            score_image   0.467
ARRB1
arrestin, beta 1; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G- protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and re [...] (418 aa)
            score_image   0.443
ARR3
arrestin 3, retinal (X-arrestin); May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins (388 aa)
            score_image   0.443
ARRB2
arrestin, beta 2 (409 aa)
            score_image   0.443
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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