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NFE2L2 NFE2L2 SUMO1 SUMO1 NFE2 NFE2 HBD HBD MAFF MAFF HBE1 HBE1 NFE2L3 NFE2L3 MAFG MAFG NFE2L1 NFE2L1 MMP1 MMP1 FOSB FOSB
"MAFG" - v-maf musculoaponeurotic fibrosarcoma oncogene homolog G in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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MAFGv-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian); Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NF- E2. Activates glob [...] (162 aa)    
Predicted Functional Partners:
NFE2L2
nuclear factor (erythroid-derived 2)-like 2; Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region (605 aa)
        score_image score_image score_image   0.999
NFE2
nuclear factor (erythroid-derived 2), 45kDa; Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron (373 aa)
        score_image score_image score_image   0.996
NFE2L3
nuclear factor (erythroid-derived 2)-like 3; Activates erythroid-specific, globin gene expression (694 aa)
        score_image   score_image   0.975
NFE2L1
nuclear factor (erythroid-derived 2)-like 1; Activates erythroid-specific, globin gene expression (772 aa)
        score_image   score_image   0.970
MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian); Interacts with the upstream promoter region of the oxytocin receptor gene. May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition. Since it lacks a putative transactivation domain, it may behave as a transcriptional repressor when it dimerize among himself. May also serve as a transcriptional activator by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. May be involved in the cellular stress response (164 aa)
        score_image score_image score_image score_image 0.965
FOSB
FBJ murine osteosarcoma viral oncogene homolog B; FosB interacts with Jun proteins enhancing their DNA binding activity (338 aa)
          score_image score_image   0.938
SUMO1
SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. [...] (101 aa)
        score_image   score_image   0.918
MMP1
matrix metallopeptidase 1 (interstitial collagenase); Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat’s mediated neurotoxicity (469 aa)
          score_image score_image   0.903
HBE1
hemoglobin, epsilon 1; The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin (147 aa)
          score_image score_image   0.902
HBD
hemoglobin, delta; Involved in oxygen transport from the lung to the various peripheral tissues (147 aa)
          score_image score_image   0.902
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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