Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | HYAL2 | hyaluronoglucosaminidase 2; Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R (473 aa) | ||||||||||||
Predicted Functional Partners:
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 | MST1R | macrophage stimulating 1 receptor (c-met-related tyrosine kinase); Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effect [...] (1400 aa) |
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0.891 | |||||||||
 | CD44 | CD44 molecule (Indian blood group) (742 aa) |
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0.878 | ||||||||||
 | HAS3 | hyaluronan synthase 3; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis (553 aa) |
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0.846 | ||||||||||
 | WWOX | WW domain containing oxidoreductase (414 aa) |
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0.844 | ||||||||||
 | HAS2 | hyaluronan synthase 2; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis (552 aa) |
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0.822 | ||||||||||
 | TGFB1 | transforming growth factor, beta 1; Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts (390 aa) |
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0.822 | ||||||||||
 | HAS1 | hyaluronan synthase 1; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis. Also able to catalyze the synthesis of chito- oligosaccharide depending on the substrate (578 aa) |
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0.821 | ||||||||||
 | KRTAP1-4 | keratin associated protein 1-4; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins (121 aa) |
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0.821 | ||||||||||
 | KRT16 | keratin 16 (473 aa) |
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0.806 | ||||||||||
 | SPAG9 | sperm associated antigen 9 (1321 aa) |
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0.751 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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