node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AURKB | BIRC5 | ENSP00000463999 | ENSP00000301633 | aurora kinase B | baculoviral IAP repeat containing 5 | 0.999 |
AURKB | BUB1 | ENSP00000463999 | ENSP00000302530 | aurora kinase B | budding uninhibited by benzimidazoles 1 homolog (yeast); Serine/threonine-protein kinase that performs 2 crucial functions during mitosis- it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Plays an important role in defining SGOL1 localization and thereby affects sister chromatid cohesion. Acts as a substrate for anaphase-promoting compl [...] | 0.991 |
AURKB | CDCA8 | ENSP00000463999 | ENSP00000316121 | aurora kinase B | cell division cycle associated 8; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment | 0.999 |
AURKB | ESPL1 | ENSP00000463999 | ENSP00000257934 | aurora kinase B | extra spindle pole bodies homolog 1 (S. cerevisiae); Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms | 0.975 |
AURKB | KIF2C | ENSP00000463999 | ENSP00000361298 | aurora kinase B | kinesin family member 2C; In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis | 0.998 |
AURKB | MAD2L1 | ENSP00000463999 | ENSP00000296509 | aurora kinase B | MAD2 mitotic arrest deficient-like 1 (yeast); Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore- spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate | 0.990 |
AURKB | RAD21 | ENSP00000463999 | ENSP00000297338 | aurora kinase B | RAD21 homolog (S. pombe); Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Als [...] | 0.978 |
AURKB | SGOL1 | ENSP00000463999 | ENSP00000263753 | aurora kinase B | shugoshin-like 1 (S. pombe) | 0.984 |
AURKB | SGOL2 | ENSP00000463999 | ENSP00000350447 | aurora kinase B | shugoshin-like 2 (S. pombe); Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Ess [...] | 0.989 |
AURKB | STAG2 | ENSP00000463999 | ENSP00000218089 | aurora kinase B | stromal antigen 2; Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis | 0.946 |
BIRC5 | AURKB | ENSP00000301633 | ENSP00000463999 | baculoviral IAP repeat containing 5 | aurora kinase B | 0.999 |
BIRC5 | BUB1 | ENSP00000301633 | ENSP00000302530 | baculoviral IAP repeat containing 5 | budding uninhibited by benzimidazoles 1 homolog (yeast); Serine/threonine-protein kinase that performs 2 crucial functions during mitosis- it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Plays an important role in defining SGOL1 localization and thereby affects sister chromatid cohesion. Acts as a substrate for anaphase-promoting compl [...] | 0.969 |
BIRC5 | CDCA8 | ENSP00000301633 | ENSP00000316121 | baculoviral IAP repeat containing 5 | cell division cycle associated 8; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment | 0.999 |
BIRC5 | ESPL1 | ENSP00000301633 | ENSP00000257934 | baculoviral IAP repeat containing 5 | extra spindle pole bodies homolog 1 (S. cerevisiae); Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms | 0.942 |
BIRC5 | KIF2C | ENSP00000301633 | ENSP00000361298 | baculoviral IAP repeat containing 5 | kinesin family member 2C; In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis | 0.953 |
BIRC5 | MAD2L1 | ENSP00000301633 | ENSP00000296509 | baculoviral IAP repeat containing 5 | MAD2 mitotic arrest deficient-like 1 (yeast); Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore- spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate | 0.981 |
BIRC5 | RAD21 | ENSP00000301633 | ENSP00000297338 | baculoviral IAP repeat containing 5 | RAD21 homolog (S. pombe); Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Als [...] | 0.925 |
BIRC5 | SGOL1 | ENSP00000301633 | ENSP00000263753 | baculoviral IAP repeat containing 5 | shugoshin-like 1 (S. pombe) | 0.929 |
BIRC5 | SGOL2 | ENSP00000301633 | ENSP00000350447 | baculoviral IAP repeat containing 5 | shugoshin-like 2 (S. pombe); Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Ess [...] | 0.986 |
BIRC5 | STAG2 | ENSP00000301633 | ENSP00000218089 | baculoviral IAP repeat containing 5 | stromal antigen 2; Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis | 0.900 |