| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ASZ1 | DNAJC28 | ENSP00000284629 | ENSP00000320303 | ankyrin repeat, SAM and basic leucine zipper domain containing 1; Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene sta [...] | DnaJ (Hsp40) homolog, subfamily C, member 28; May have a role in protein folding or as a chaperone | 0.457 |
| ASZ1 | FAM3B | ENSP00000284629 | ENSP00000350673 | ankyrin repeat, SAM and basic leucine zipper domain containing 1; Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene sta [...] | family with sequence similarity 3, member B; Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner | 0.581 |
| ASZ1 | MPLKIP | ENSP00000284629 | ENSP00000304553 | ankyrin repeat, SAM and basic leucine zipper domain containing 1; Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene sta [...] | M-phase specific PLK1 interacting protein; May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis | 0.473 |
| C14orf1 | DNAJC28 | ENSP00000256319 | ENSP00000320303 | chromosome 14 open reading frame 1 | DnaJ (Hsp40) homolog, subfamily C, member 28; May have a role in protein folding or as a chaperone | 0.483 |
| C14orf1 | FAM3B | ENSP00000256319 | ENSP00000350673 | chromosome 14 open reading frame 1 | family with sequence similarity 3, member B; Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner | 0.583 |
| C14orf1 | SETD4 | ENSP00000256319 | ENSP00000329189 | chromosome 14 open reading frame 1 | SET domain containing 4 | 0.485 |
| CCL2 | FAM3B | ENSP00000225831 | ENSP00000350673 | chemokine (C-C motif) ligand 2; Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis | family with sequence similarity 3, member B; Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner | 0.802 |
| CCL2 | IFNG | ENSP00000225831 | ENSP00000229135 | chemokine (C-C motif) ligand 2; Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis | interferon, gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity) | 0.485 |
| DNAJC28 | ASZ1 | ENSP00000320303 | ENSP00000284629 | DnaJ (Hsp40) homolog, subfamily C, member 28; May have a role in protein folding or as a chaperone | ankyrin repeat, SAM and basic leucine zipper domain containing 1; Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene sta [...] | 0.457 |
| DNAJC28 | C14orf1 | ENSP00000320303 | ENSP00000256319 | DnaJ (Hsp40) homolog, subfamily C, member 28; May have a role in protein folding or as a chaperone | chromosome 14 open reading frame 1 | 0.483 |
| DNAJC28 | FAM3B | ENSP00000320303 | ENSP00000350673 | DnaJ (Hsp40) homolog, subfamily C, member 28; May have a role in protein folding or as a chaperone | family with sequence similarity 3, member B; Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner | 0.638 |
| DNAJC28 | MPLKIP | ENSP00000320303 | ENSP00000304553 | DnaJ (Hsp40) homolog, subfamily C, member 28; May have a role in protein folding or as a chaperone | M-phase specific PLK1 interacting protein; May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis | 0.813 |
| DNAJC28 | SETD4 | ENSP00000320303 | ENSP00000329189 | DnaJ (Hsp40) homolog, subfamily C, member 28; May have a role in protein folding or as a chaperone | SET domain containing 4 | 0.584 |
| FAM3B | ASZ1 | ENSP00000350673 | ENSP00000284629 | family with sequence similarity 3, member B; Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner | ankyrin repeat, SAM and basic leucine zipper domain containing 1; Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene sta [...] | 0.581 |
| FAM3B | C14orf1 | ENSP00000350673 | ENSP00000256319 | family with sequence similarity 3, member B; Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner | chromosome 14 open reading frame 1 | 0.583 |
| FAM3B | CCL2 | ENSP00000350673 | ENSP00000225831 | family with sequence similarity 3, member B; Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner | chemokine (C-C motif) ligand 2; Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis | 0.802 |
| FAM3B | DNAJC28 | ENSP00000350673 | ENSP00000320303 | family with sequence similarity 3, member B; Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner | DnaJ (Hsp40) homolog, subfamily C, member 28; May have a role in protein folding or as a chaperone | 0.638 |
| FAM3B | FOXO1 | ENSP00000350673 | ENSP00000368880 | family with sequence similarity 3, member B; Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner | forkhead box O1; Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5’-TT[G/A]TTTTG-3’ and the related Daf-16 family binding element (DBE) with consensus sequence 5’- TT[G/A]TTTAC-3’. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts syngernistically with ATF4 to suppress osteocalcin/BGL [...] | 0.800 |
| FAM3B | IFNG | ENSP00000350673 | ENSP00000229135 | family with sequence similarity 3, member B; Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner | interferon, gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity) | 0.779 |
| FAM3B | LTN1 | ENSP00000350673 | ENSP00000373846 | family with sequence similarity 3, member B; Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner | listerin E3 ubiquitin protein ligase 1 | 0.543 |
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