Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
TLE4 TLE4 LEF1 LEF1 RAG2 RAG2 MYB MYB PAX5 PAX5 DAXX DAXX RUNX1 RUNX1 ETS1 ETS1 STAT5A STAT5A PRDM1 PRDM1 EBF1 EBF1
"PAX5" - paired box 5 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PAX5paired box 5 (391 aa)    
Predicted Functional Partners:
MYB
v-myb myeloblastosis viral oncogene homolog (avian) (761 aa)
        score_image score_image score_image   0.995
RAG2
recombination activating gene 2; Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps- a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3’-hydroxyl group that can attack the phosphodiest [...] (527 aa)
          score_image score_image   0.993
LEF1
lymphoid enhancer-binding factor 1; Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 [...] (399 aa)
        score_image score_image score_image   0.990
EBF1
early B-cell factor 1; Transcriptional activator which recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (By similarity) (591 aa)
        score_image   score_image   0.983
DAXX
death-domain associated protein (740 aa)
        score_image   score_image   0.977
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) (773 aa)
        score_image   score_image   0.976
RUNX1
runt-related transcription factor 1 (480 aa)
        score_image   score_image   0.976
ETS1
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian); Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion (485 aa)
        score_image   score_image   0.961
PRDM1
PR domain containing 1, with ZNF domain; Transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells (825 aa)
            score_image   0.951
STAT5A
signal transducer and activator of transcription 5A; Carries out a dual function- signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation (794 aa)
            score_image   0.949
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: low (27%)