node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABAT | ALDH1A3 | ENSP00000268251 | ENSP00000332256 | 4-aminobutyrate aminotransferase; Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine | aldehyde dehydrogenase 1 family, member A3; Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity) | 0.943 |
ABAT | ALDH4A1 | ENSP00000268251 | ENSP00000290597 | 4-aminobutyrate aminotransferase; Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine | aldehyde dehydrogenase 4 family, member A1 | 0.540 |
ABAT | ALDH7A1 | ENSP00000268251 | ENSP00000387123 | 4-aminobutyrate aminotransferase; Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine | aldehyde dehydrogenase 7 family, member A1; Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism | 0.945 |
ABAT | ALDH9A1 | ENSP00000268251 | ENSP00000346827 | 4-aminobutyrate aminotransferase; Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine | aldehyde dehydrogenase 9 family, member A1; Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction | 0.949 |
ABAT | GAD1 | ENSP00000268251 | ENSP00000350928 | 4-aminobutyrate aminotransferase; Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine | glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA | 0.987 |
ABAT | GLUL | ENSP00000268251 | ENSP00000307900 | 4-aminobutyrate aminotransferase; Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine | glutamate-ammonia ligase; This enzyme has 2 functions- it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts | 0.558 |
ALDH1A3 | ABAT | ENSP00000332256 | ENSP00000268251 | aldehyde dehydrogenase 1 family, member A3; Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity) | 4-aminobutyrate aminotransferase; Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine | 0.943 |
ALDH1A3 | CAD | ENSP00000332256 | ENSP00000264705 | aldehyde dehydrogenase 1 family, member A3; Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity) | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | 0.442 |
ALDH1A3 | GAD1 | ENSP00000332256 | ENSP00000350928 | aldehyde dehydrogenase 1 family, member A3; Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity) | glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA | 0.928 |
ALDH4A1 | ABAT | ENSP00000290597 | ENSP00000268251 | aldehyde dehydrogenase 4 family, member A1 | 4-aminobutyrate aminotransferase; Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine | 0.540 |
ALDH4A1 | ALDH7A1 | ENSP00000290597 | ENSP00000387123 | aldehyde dehydrogenase 4 family, member A1 | aldehyde dehydrogenase 7 family, member A1; Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism | 0.852 |
ALDH4A1 | ALDH9A1 | ENSP00000290597 | ENSP00000346827 | aldehyde dehydrogenase 4 family, member A1 | aldehyde dehydrogenase 9 family, member A1; Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction | 0.829 |
ALDH4A1 | CAD | ENSP00000290597 | ENSP00000264705 | aldehyde dehydrogenase 4 family, member A1 | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | 0.883 |
ALDH4A1 | GAD1 | ENSP00000290597 | ENSP00000350928 | aldehyde dehydrogenase 4 family, member A1 | glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA | 0.927 |
ALDH4A1 | GLS | ENSP00000290597 | ENSP00000317379 | aldehyde dehydrogenase 4 family, member A1 | glutaminase; Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity | 0.914 |
ALDH4A1 | GLUL | ENSP00000290597 | ENSP00000307900 | aldehyde dehydrogenase 4 family, member A1 | glutamate-ammonia ligase; This enzyme has 2 functions- it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts | 0.945 |
ALDH7A1 | ABAT | ENSP00000387123 | ENSP00000268251 | aldehyde dehydrogenase 7 family, member A1; Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism | 4-aminobutyrate aminotransferase; Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine | 0.945 |
ALDH7A1 | ALDH4A1 | ENSP00000387123 | ENSP00000290597 | aldehyde dehydrogenase 7 family, member A1; Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism | aldehyde dehydrogenase 4 family, member A1 | 0.852 |
ALDH7A1 | CAD | ENSP00000387123 | ENSP00000264705 | aldehyde dehydrogenase 7 family, member A1; Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | 0.883 |
ALDH7A1 | GAD1 | ENSP00000387123 | ENSP00000350928 | aldehyde dehydrogenase 7 family, member A1; Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism | glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA | 0.979 |