ICA1L protein (Homo sapiens) - STRING network view

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ICA1L

islet cell autoantigen 1,69kDa-like (482 aa)

Predicted Functional Partners:

SLC35D3

0.576

ERGIC1

0.566

SGSM1

0.488

SGSM2

0.488

RAB2B

0.482

RAB2A

0.482

DOPEY2

0.479

TMED7

0.457

TICAM2

0.457

TMED3

0.457

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DOPEY2	ICA1L	ENSP00000382104	ENSP00000351047	dopey family member 2; May be involved in protein traffic between late Golgi and early endosomes (By similarity)	islet cell autoantigen 1,69kDa-like	0.479
ERGIC1	ICA1L	ENSP00000377374	ENSP00000351047	endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1; Possible role in transport between endoplasmic reticulum and Golgi	islet cell autoantigen 1,69kDa-like	0.566
ERGIC1	TICAM2	ENSP00000377374	ENSP00000386341	endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1; Possible role in transport between endoplasmic reticulum and Golgi	toll-like receptor adaptor molecule 2; Functions in LPS-TLR4 signaling to regulate the MYD88- independent pathway during the innate immune response to LPS. Also involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1	0.607
ERGIC1	TMED3	ENSP00000377374	ENSP00000299705	endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1; Possible role in transport between endoplasmic reticulum and Golgi	transmembrane emp24 protein transport domain containing 3; Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network	0.698
ERGIC1	TMED7	ENSP00000377374	ENSP00000405926	endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1; Possible role in transport between endoplasmic reticulum and Golgi	transmembrane emp24 protein transport domain containing 7; Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Appears to play a role in the biosynthesis of secreted cargo including processing and post- translational modifications	0.607
ICA1L	DOPEY2	ENSP00000351047	ENSP00000382104	islet cell autoantigen 1,69kDa-like	dopey family member 2; May be involved in protein traffic between late Golgi and early endosomes (By similarity)	0.479
ICA1L	ERGIC1	ENSP00000351047	ENSP00000377374	islet cell autoantigen 1,69kDa-like	endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1; Possible role in transport between endoplasmic reticulum and Golgi	0.566
ICA1L	RAB2A	ENSP00000351047	ENSP00000262646	islet cell autoantigen 1,69kDa-like	RAB2A, member RAS oncogene family; Required for protein transport from the endoplasmic reticulum to the Golgi complex	0.482
ICA1L	RAB2B	ENSP00000351047	ENSP00000380869	islet cell autoantigen 1,69kDa-like	RAB2B, member RAS oncogene family; Required for protein transport from the endoplasmic reticulum to the Golgi complex (Potential)	0.482
ICA1L	SGSM1	ENSP00000351047	ENSP00000383212	islet cell autoantigen 1,69kDa-like	small G protein signaling modulator 1	0.488
ICA1L	SGSM2	ENSP00000351047	ENSP00000268989	islet cell autoantigen 1,69kDa-like	small G protein signaling modulator 2	0.488
ICA1L	SLC35D3	ENSP00000351047	ENSP00000333591	islet cell autoantigen 1,69kDa-like	solute carrier family 35, member D3; May play a role in hemostasis as a regulator of the biosynthesis of platelet-dense granules (By similarity)	0.576
ICA1L	TICAM2	ENSP00000351047	ENSP00000386341	islet cell autoantigen 1,69kDa-like	toll-like receptor adaptor molecule 2; Functions in LPS-TLR4 signaling to regulate the MYD88- independent pathway during the innate immune response to LPS. Also involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1	0.457
ICA1L	TMED3	ENSP00000351047	ENSP00000299705	islet cell autoantigen 1,69kDa-like	transmembrane emp24 protein transport domain containing 3; Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network	0.457
ICA1L	TMED7	ENSP00000351047	ENSP00000405926	islet cell autoantigen 1,69kDa-like	transmembrane emp24 protein transport domain containing 7; Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Appears to play a role in the biosynthesis of secreted cargo including processing and post- translational modifications	0.457
RAB2A	ICA1L	ENSP00000262646	ENSP00000351047	RAB2A, member RAS oncogene family; Required for protein transport from the endoplasmic reticulum to the Golgi complex	islet cell autoantigen 1,69kDa-like	0.482
RAB2A	SGSM1	ENSP00000262646	ENSP00000383212	RAB2A, member RAS oncogene family; Required for protein transport from the endoplasmic reticulum to the Golgi complex	small G protein signaling modulator 1	0.545
RAB2A	SGSM2	ENSP00000262646	ENSP00000268989	RAB2A, member RAS oncogene family; Required for protein transport from the endoplasmic reticulum to the Golgi complex	small G protein signaling modulator 2	0.539
RAB2B	ICA1L	ENSP00000380869	ENSP00000351047	RAB2B, member RAS oncogene family; Required for protein transport from the endoplasmic reticulum to the Golgi complex (Potential)	islet cell autoantigen 1,69kDa-like	0.482
RAB2B	SGSM1	ENSP00000380869	ENSP00000383212	RAB2B, member RAS oncogene family; Required for protein transport from the endoplasmic reticulum to the Golgi complex (Potential)	small G protein signaling modulator 1	0.416

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