| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ALK | ZC3HC1 | ENSP00000373700 | ENSP00000351052 | anaplastic lymphoma receptor tyrosine kinase; Neuronal orphan receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 [...] | zinc finger, C3HC-type containing 1 | 0.940 |
| CCNB1 | CUL1 | ENSP00000256442 | ENSP00000326804 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | cullin 1; Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate [...] | 0.795 |
| CCNB1 | SKP1 | ENSP00000256442 | ENSP00000231487 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] | 0.722 |
| CCNB1 | UBC | ENSP00000256442 | ENSP00000344818 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | ubiquitin C | 0.999 |
| CCNB1 | ZC3HC1 | ENSP00000256442 | ENSP00000351052 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | zinc finger, C3HC-type containing 1 | 0.858 |
| CNNM2 | HHIPL1 | ENSP00000358894 | ENSP00000330601 | cyclin M2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity) | HHIP-like 1 | 0.563 |
| CNNM2 | MMGT1 | ENSP00000358894 | ENSP00000306220 | cyclin M2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity) | membrane magnesium transporter 1; Mediates Mg(2+) transport (By similarity) | 0.566 |
| CNNM2 | NIPA2 | ENSP00000358894 | ENSP00000337618 | cyclin M2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity) | non imprinted in Prader-Willi/Angelman syndrome 2; Acts as a selective Mg(2+) transporter (By similarity) | 0.519 |
| CNNM2 | UBC | ENSP00000358894 | ENSP00000344818 | cyclin M2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity) | ubiquitin C | 0.828 |
| CNNM2 | ZC3HC1 | ENSP00000358894 | ENSP00000351052 | cyclin M2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity) | zinc finger, C3HC-type containing 1 | 0.618 |
| CUL1 | CCNB1 | ENSP00000326804 | ENSP00000256442 | cullin 1; Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate [...] | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | 0.795 |
| CUL1 | SKP1 | ENSP00000326804 | ENSP00000231487 | cullin 1; Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate [...] | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] | 0.999 |
| CUL1 | UBC | ENSP00000326804 | ENSP00000344818 | cullin 1; Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate [...] | ubiquitin C | 0.999 |
| CUL1 | ZC3HC1 | ENSP00000326804 | ENSP00000351052 | cullin 1; Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate [...] | zinc finger, C3HC-type containing 1 | 0.825 |
| HHIPL1 | CNNM2 | ENSP00000330601 | ENSP00000358894 | HHIP-like 1 | cyclin M2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity) | 0.563 |
| HHIPL1 | ZC3HC1 | ENSP00000330601 | ENSP00000351052 | HHIP-like 1 | zinc finger, C3HC-type containing 1 | 0.640 |
| MMGT1 | CNNM2 | ENSP00000306220 | ENSP00000358894 | membrane magnesium transporter 1; Mediates Mg(2+) transport (By similarity) | cyclin M2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity) | 0.566 |
| MMGT1 | NIPA2 | ENSP00000306220 | ENSP00000337618 | membrane magnesium transporter 1; Mediates Mg(2+) transport (By similarity) | non imprinted in Prader-Willi/Angelman syndrome 2; Acts as a selective Mg(2+) transporter (By similarity) | 0.565 |
| MMGT1 | NIPAL1 | ENSP00000306220 | ENSP00000295461 | membrane magnesium transporter 1; Mediates Mg(2+) transport (By similarity) | NIPA-like domain containing 1; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+), Cu(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity) | 0.611 |
| MMGT1 | UBC | ENSP00000306220 | ENSP00000344818 | membrane magnesium transporter 1; Mediates Mg(2+) transport (By similarity) | ubiquitin C | 0.632 |
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