Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | SUSD2 | sushi domain containing 2 (822 aa) | ||||||||||||
Predicted Functional Partners:
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 | LGALS1 | lectin, galactoside-binding, soluble, 1; May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase (135 aa) |
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0.909 | |||||||||
 | C14orf37 | chromosome 14 open reading frame 37 (774 aa) |
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0.692 | ||||||||||
 | CACNA2D4 | calcium channel, voltage-dependent, alpha 2/delta subunit 4; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel (1137 aa) |
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0.629 | ||||||||||
 | ADCY6 | adenylate cyclase 6; Membrane-bound, calcium-inhibitable adenylyl cyclase (By similarity) (1168 aa) |
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0.624 | ||||||||||
 | ATP11A | ATPase, class VI, type 11A (1134 aa) |
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0.610 | ||||||||||
 | ATP8A2 | ATPase, aminophospholipid transporter, class I, type 8A, member 2 (1188 aa) |
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0.605 | ||||||||||
 | ADCY5 | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase (1261 aa) |
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0.599 | ||||||||||
 | CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) (By similarity) (1091 aa) |
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0.561 | ||||||||||
 | ATP11C | ATPase, class VI, type 11C (1132 aa) |
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0.556 | ||||||||||
 | ATP8A1 | ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1; May play a role in the transport of aminophospholipids from the outer to the inner leaflet of various membranes and the maintenance of asymmetric distribution of phospholipids, mainly in secretory vesicles (1164 aa) |
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0.548 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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