node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDH17 | CDHR5 | ENSP00000027335 | ENSP00000351118 | cadherin 17, LI cadherin (liver-intestine); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport | cadherin-related family member 5 | 0.609 |
CDH17 | USH1C | ENSP00000027335 | ENSP00000005226 | cadherin 17, LI cadherin (liver-intestine); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport | Usher syndrome 1C (autosomal recessive, severe); Required for normal development and maintenance of cochlear hair cell bundles. Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing (By similarity) | 0.591 |
CDHR2 | CDHR5 | ENSP00000261944 | ENSP00000351118 | cadherin-related family member 2; Role in contact inhibition at the lateral surface of epithelial cells | cadherin-related family member 5 | 0.760 |
CDHR2 | MYO7B | ENSP00000261944 | ENSP00000386461 | cadherin-related family member 2; Role in contact inhibition at the lateral surface of epithelial cells | myosin VIIB; Myosins are actin-based motor molecules with ATPase activity. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. May be have a role in the apical membranes of transporting epithelia (By similarity) | 0.587 |
CDHR2 | USH1C | ENSP00000261944 | ENSP00000005226 | cadherin-related family member 2; Role in contact inhibition at the lateral surface of epithelial cells | Usher syndrome 1C (autosomal recessive, severe); Required for normal development and maintenance of cochlear hair cell bundles. Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing (By similarity) | 0.655 |
CDHR5 | CDH17 | ENSP00000351118 | ENSP00000027335 | cadherin-related family member 5 | cadherin 17, LI cadherin (liver-intestine); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport | 0.609 |
CDHR5 | CDHR2 | ENSP00000351118 | ENSP00000261944 | cadherin-related family member 5 | cadherin-related family member 2; Role in contact inhibition at the lateral surface of epithelial cells | 0.760 |
CDHR5 | DEAF1 | ENSP00000351118 | ENSP00000371846 | cadherin-related family member 5 | deformed epidermal autoregulatory factor 1 (Drosophila) | 0.492 |
CDHR5 | DRD4 | ENSP00000351118 | ENSP00000176183 | cadherin-related family member 5 | dopamine receptor D4 | 0.618 |
CDHR5 | KCNH2 | ENSP00000351118 | ENSP00000262186 | cadherin-related family member 5 | potassium voltage-gated channel, subfamily H (eag-related), member 2; Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1 | 0.497 |
CDHR5 | KCNH6 | ENSP00000351118 | ENSP00000463533 | cadherin-related family member 5 | potassium voltage-gated channel, subfamily H (eag-related), member 6; Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, rectifying current (By similarity). Channel properties may be modulated by cAMP and subunit assembly | 0.497 |
CDHR5 | KCNH7 | ENSP00000351118 | ENSP00000331727 | cadherin-related family member 5 | potassium voltage-gated channel, subfamily H (eag-related), member 7; Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties may be modulated by cAMP and subunit assembly | 0.580 |
CDHR5 | KRTAP6-3 | ENSP00000351118 | ENSP00000375482 | cadherin-related family member 5 | keratin associated protein 6-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins | 0.472 |
CDHR5 | MYO7B | ENSP00000351118 | ENSP00000386461 | cadherin-related family member 5 | myosin VIIB; Myosins are actin-based motor molecules with ATPase activity. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. May be have a role in the apical membranes of transporting epithelia (By similarity) | 0.634 |
CDHR5 | USH1C | ENSP00000351118 | ENSP00000005226 | cadherin-related family member 5 | Usher syndrome 1C (autosomal recessive, severe); Required for normal development and maintenance of cochlear hair cell bundles. Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing (By similarity) | 0.679 |
DEAF1 | CDHR5 | ENSP00000371846 | ENSP00000351118 | deformed epidermal autoregulatory factor 1 (Drosophila) | cadherin-related family member 5 | 0.492 |
DEAF1 | DRD4 | ENSP00000371846 | ENSP00000176183 | deformed epidermal autoregulatory factor 1 (Drosophila) | dopamine receptor D4 | 0.594 |
DEAF1 | KCNH2 | ENSP00000371846 | ENSP00000262186 | deformed epidermal autoregulatory factor 1 (Drosophila) | potassium voltage-gated channel, subfamily H (eag-related), member 2; Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1 | 0.495 |
DEAF1 | KCNH6 | ENSP00000371846 | ENSP00000463533 | deformed epidermal autoregulatory factor 1 (Drosophila) | potassium voltage-gated channel, subfamily H (eag-related), member 6; Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, rectifying current (By similarity). Channel properties may be modulated by cAMP and subunit assembly | 0.487 |
DEAF1 | KCNH7 | ENSP00000371846 | ENSP00000331727 | deformed epidermal autoregulatory factor 1 (Drosophila) | potassium voltage-gated channel, subfamily H (eag-related), member 7; Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties may be modulated by cAMP and subunit assembly | 0.532 |