WTAP protein (Homo sapiens) - STRING network view

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WTAP

Wilms tumor 1 associated protein; Regulates G2/M cell-cycle transition by binding to the 3’ UTR of CCNA2, which enhances its stability. Impairs WT1 DNA- binding ability and inhibits expression of WT1 target genes. May be involved in mRNA splicing regulation (396 aa)

Predicted Functional Partners:

METTL14

0.989

METTL3

0.989

KIAA1429

0.978

WT1

0.961

UBC

0.889

CCNA2

0.886

IGF1

0.800

GPR132

0.757

FKBP3

0.682

FKBP1A

0.677

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCNA2	GPR132	ENSP00000274026	ENSP00000328818	cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions	G protein-coupled receptor 132; Receptor for an unknown ligand. Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May serve as a mechanism for T- and B-cells, and other cell types, to slow their proliferation and repair damaged DNA to ensure proper replication	0.607
CCNA2	UBC	ENSP00000274026	ENSP00000344818	cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions	ubiquitin C	0.993
CCNA2	WTAP	ENSP00000274026	ENSP00000351141	cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions	Wilms tumor 1 associated protein; Regulates G2/M cell-cycle transition by binding to the 3’ UTR of CCNA2, which enhances its stability. Impairs WT1 DNA- binding ability and inhibits expression of WT1 target genes. May be involved in mRNA splicing regulation	0.886
FKBP1A	UBC	ENSP00000371138	ENSP00000344818	FK506 binding protein 1A, 12kDa; Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ubiquitin C	0.882
FKBP1A	WTAP	ENSP00000371138	ENSP00000351141	FK506 binding protein 1A, 12kDa; Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	Wilms tumor 1 associated protein; Regulates G2/M cell-cycle transition by binding to the 3’ UTR of CCNA2, which enhances its stability. Impairs WT1 DNA- binding ability and inhibits expression of WT1 target genes. May be involved in mRNA splicing regulation	0.677
FKBP3	UBC	ENSP00000216330	ENSP00000344818	FK506 binding protein 3, 25kDa; FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins	ubiquitin C	0.770
FKBP3	WTAP	ENSP00000216330	ENSP00000351141	FK506 binding protein 3, 25kDa; FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins	Wilms tumor 1 associated protein; Regulates G2/M cell-cycle transition by binding to the 3’ UTR of CCNA2, which enhances its stability. Impairs WT1 DNA- binding ability and inhibits expression of WT1 target genes. May be involved in mRNA splicing regulation	0.682
GPR132	CCNA2	ENSP00000328818	ENSP00000274026	G protein-coupled receptor 132; Receptor for an unknown ligand. Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May serve as a mechanism for T- and B-cells, and other cell types, to slow their proliferation and repair damaged DNA to ensure proper replication	cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions	0.607
GPR132	WTAP	ENSP00000328818	ENSP00000351141	G protein-coupled receptor 132; Receptor for an unknown ligand. Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May serve as a mechanism for T- and B-cells, and other cell types, to slow their proliferation and repair damaged DNA to ensure proper replication	Wilms tumor 1 associated protein; Regulates G2/M cell-cycle transition by binding to the 3’ UTR of CCNA2, which enhances its stability. Impairs WT1 DNA- binding ability and inhibits expression of WT1 target genes. May be involved in mRNA splicing regulation	0.757
IGF1	WTAP	ENSP00000302665	ENSP00000351141	insulin-like growth factor 1 (somatomedin C); The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake	Wilms tumor 1 associated protein; Regulates G2/M cell-cycle transition by binding to the 3’ UTR of CCNA2, which enhances its stability. Impairs WT1 DNA- binding ability and inhibits expression of WT1 target genes. May be involved in mRNA splicing regulation	0.800
KIAA1429	METTL14	ENSP00000297591	ENSP00000373474	KIAA1429	methyltransferase like 14; Probable methyltransferase (By similarity)	0.474
KIAA1429	UBC	ENSP00000297591	ENSP00000344818	KIAA1429	ubiquitin C	0.795
KIAA1429	WTAP	ENSP00000297591	ENSP00000351141	KIAA1429	Wilms tumor 1 associated protein; Regulates G2/M cell-cycle transition by binding to the 3’ UTR of CCNA2, which enhances its stability. Impairs WT1 DNA- binding ability and inhibits expression of WT1 target genes. May be involved in mRNA splicing regulation	0.978
METTL14	KIAA1429	ENSP00000373474	ENSP00000297591	methyltransferase like 14; Probable methyltransferase (By similarity)	KIAA1429	0.474
METTL14	METTL3	ENSP00000373474	ENSP00000298717	methyltransferase like 14; Probable methyltransferase (By similarity)	methyltransferase like 3; N6-methyltransferase that methylates adenosine residues of some mRNAs. N6-methyladenosine (m6A), which is present at internal sites of some mRNAs, may play a role in the efficiency of mRNA splicing, transport or translation	0.989
METTL14	UBC	ENSP00000373474	ENSP00000344818	methyltransferase like 14; Probable methyltransferase (By similarity)	ubiquitin C	0.620
METTL14	WTAP	ENSP00000373474	ENSP00000351141	methyltransferase like 14; Probable methyltransferase (By similarity)	Wilms tumor 1 associated protein; Regulates G2/M cell-cycle transition by binding to the 3’ UTR of CCNA2, which enhances its stability. Impairs WT1 DNA- binding ability and inhibits expression of WT1 target genes. May be involved in mRNA splicing regulation	0.989
METTL3	METTL14	ENSP00000298717	ENSP00000373474	methyltransferase like 3; N6-methyltransferase that methylates adenosine residues of some mRNAs. N6-methyladenosine (m6A), which is present at internal sites of some mRNAs, may play a role in the efficiency of mRNA splicing, transport or translation	methyltransferase like 14; Probable methyltransferase (By similarity)	0.989
METTL3	UBC	ENSP00000298717	ENSP00000344818	methyltransferase like 3; N6-methyltransferase that methylates adenosine residues of some mRNAs. N6-methyladenosine (m6A), which is present at internal sites of some mRNAs, may play a role in the efficiency of mRNA splicing, transport or translation	ubiquitin C	0.483
METTL3	WTAP	ENSP00000298717	ENSP00000351141	methyltransferase like 3; N6-methyltransferase that methylates adenosine residues of some mRNAs. N6-methyladenosine (m6A), which is present at internal sites of some mRNAs, may play a role in the efficiency of mRNA splicing, transport or translation	Wilms tumor 1 associated protein; Regulates G2/M cell-cycle transition by binding to the 3’ UTR of CCNA2, which enhances its stability. Impairs WT1 DNA- binding ability and inhibits expression of WT1 target genes. May be involved in mRNA splicing regulation	0.989

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