COL6A6 protein (Homo sapiens) - STRING network view

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COL6A6

collagen, type VI, alpha 6; Collagen VI acts as a cell-binding protein (By similarity) (2263 aa)

Predicted Functional Partners:

ITGA7

0.850

ITGA5

0.831

ITGA6

0.830

PTK2

0.826

ITGA1

0.817

ITGB1

0.817

ITGA8

0.810

ITGA2B

0.810

ITGA9

0.808

ENSG00000259753

0.807

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
COL6A6	ENSG00000259753	ENSP00000351310	ENSP00000456711	collagen, type VI, alpha 6; Collagen VI acts as a cell-binding protein (By similarity)	Integrin beta	0.807
COL6A6	ITGA1	ENSP00000351310	ENSP00000282588	collagen, type VI, alpha 6; Collagen VI acts as a cell-binding protein (By similarity)	integrin, alpha 1; Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G- E-R in collagen	0.817
COL6A6	ITGA2B	ENSP00000351310	ENSP00000262407	collagen, type VI, alpha 6; Collagen VI acts as a cell-binding protein (By similarity)	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41); Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface	0.810
COL6A6	ITGA5	ENSP00000351310	ENSP00000293379	collagen, type VI, alpha 6; Collagen VI acts as a cell-binding protein (By similarity)	integrin, alpha 5 (fibronectin receptor, alpha polypeptide); Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi’s sarcoma lesions	0.831
COL6A6	ITGA6	ENSP00000351310	ENSP00000386896	collagen, type VI, alpha 6; Collagen VI acts as a cell-binding protein (By similarity)	integrin, alpha 6	0.830
COL6A6	ITGA7	ENSP00000351310	ENSP00000452120	collagen, type VI, alpha 6; Collagen VI acts as a cell-binding protein (By similarity)	integrin, alpha 7	0.850
COL6A6	ITGA8	ENSP00000351310	ENSP00000367316	collagen, type VI, alpha 6; Collagen VI acts as a cell-binding protein (By similarity)	integrin, alpha 8; Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons	0.810
COL6A6	ITGA9	ENSP00000351310	ENSP00000264741	collagen, type VI, alpha 6; Collagen VI acts as a cell-binding protein (By similarity)	integrin, alpha 9; Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G- I-E-L in cytotactin	0.808
COL6A6	ITGB1	ENSP00000351310	ENSP00000303351	collagen, type VI, alpha 6; Collagen VI acts as a cell-binding protein (By similarity)	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.817
COL6A6	PTK2	ENSP00000351310	ENSP00000341189	collagen, type VI, alpha 6; Collagen VI acts as a cell-binding protein (By similarity)	PTK2 protein tyrosine kinase 2; Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; req [...]	0.826
ENSG00000259753	COL6A6	ENSP00000456711	ENSP00000351310	Integrin beta	collagen, type VI, alpha 6; Collagen VI acts as a cell-binding protein (By similarity)	0.807
ENSG00000259753	ITGA1	ENSP00000456711	ENSP00000282588	Integrin beta	integrin, alpha 1; Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G- E-R in collagen	0.874
ENSG00000259753	ITGA2B	ENSP00000456711	ENSP00000262407	Integrin beta	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41); Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface	0.965
ENSG00000259753	ITGA5	ENSP00000456711	ENSP00000293379	Integrin beta	integrin, alpha 5 (fibronectin receptor, alpha polypeptide); Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi’s sarcoma lesions	0.965
ENSG00000259753	ITGA6	ENSP00000456711	ENSP00000386896	Integrin beta	integrin, alpha 6	0.932
ENSG00000259753	ITGA7	ENSP00000456711	ENSP00000452120	Integrin beta	integrin, alpha 7	0.931
ENSG00000259753	ITGA8	ENSP00000456711	ENSP00000367316	Integrin beta	integrin, alpha 8; Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons	0.937
ENSG00000259753	ITGA9	ENSP00000456711	ENSP00000264741	Integrin beta	integrin, alpha 9; Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G- I-E-L in cytotactin	0.940
ENSG00000259753	PTK2	ENSP00000456711	ENSP00000341189	Integrin beta	PTK2 protein tyrosine kinase 2; Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; req [...]	0.858
ITGA1	COL6A6	ENSP00000282588	ENSP00000351310	integrin, alpha 1; Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G- E-R in collagen	collagen, type VI, alpha 6; Collagen VI acts as a cell-binding protein (By similarity)	0.817

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