| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DBNL | ENSG00000258555 | ENSP00000417653 | ENSP00000351480 | drebrin-like; Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G- actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse [...] | Uncharacterized protein | 0.434 |
| DBNL | POTEE | ENSP00000417653 | ENSP00000439189 | drebrin-like; Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G- actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse [...] | POTE ankyrin domain family member E | 0.715 |
| DBNL | POTEF | ENSP00000417653 | ENSP00000350052 | drebrin-like; Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G- actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse [...] | POTE ankyrin domain family, member F | 0.722 |
| DBNL | POTEI | ENSP00000417653 | ENSP00000392718 | drebrin-like; Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G- actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse [...] | POTE ankyrin domain family, member I | 0.715 |
| DBNL | POTEJ | ENSP00000417653 | ENSP00000387176 | drebrin-like; Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G- actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse [...] | POTE ankyrin domain family, member J | 0.715 |
| EIF1AD | ENSG00000258555 | ENSP00000309175 | ENSP00000351480 | eukaryotic translation initiation factor 1A domain containing; Plays a role into cellular response to oxidative stress. Decreases cell proliferation | Uncharacterized protein | 0.601 |
| ENSG00000258555 | DBNL | ENSP00000351480 | ENSP00000417653 | Uncharacterized protein | drebrin-like; Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G- actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse [...] | 0.434 |
| ENSG00000258555 | EIF1AD | ENSP00000351480 | ENSP00000309175 | Uncharacterized protein | eukaryotic translation initiation factor 1A domain containing; Plays a role into cellular response to oxidative stress. Decreases cell proliferation | 0.601 |
| ENSG00000258555 | POTEE | ENSP00000351480 | ENSP00000439189 | Uncharacterized protein | POTE ankyrin domain family member E | 0.422 |
| ENSG00000258555 | POTEF | ENSP00000351480 | ENSP00000350052 | Uncharacterized protein | POTE ankyrin domain family, member F | 0.422 |
| ENSG00000258555 | POTEI | ENSP00000351480 | ENSP00000392718 | Uncharacterized protein | POTE ankyrin domain family, member I | 0.422 |
| ENSG00000258555 | POTEJ | ENSP00000351480 | ENSP00000387176 | Uncharacterized protein | POTE ankyrin domain family, member J | 0.422 |
| ENSG00000258555 | RAB39A | ENSP00000351480 | ENSP00000322594 | Uncharacterized protein | RAB39A, member RAS oncogene family; Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in vesicular trafficking. Plays a role in the fusion of phagosomes with lysosomes | 0.504 |
| ENSG00000258555 | SETDB2 | ENSP00000351480 | ENSP00000326477 | Uncharacterized protein | SET domain, bifurcated 2; Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates ’Lys-9’ of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis | 0.401 |
| ENSG00000258555 | UPB1 | ENSP00000351480 | ENSP00000324343 | Uncharacterized protein | ureidopropionase, beta; Converts N-carbamyl-beta-aminoisobutyric acid and N- carbamyl-beta-alanine to, respectively, beta-aminoisobutyric acid and beta-alanine, ammonia and carbon dioxide | 0.488 |
| ENSG00000258555 | USP10 | ENSP00000351480 | ENSP00000219473 | Uncharacterized protein | ubiquitin specific peptidase 10; Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability- in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels- mediates deubiquitination of BECN1, a key [...] | 0.402 |
| POTEE | DBNL | ENSP00000439189 | ENSP00000417653 | POTE ankyrin domain family member E | drebrin-like; Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G- actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse [...] | 0.715 |
| POTEE | ENSG00000258555 | ENSP00000439189 | ENSP00000351480 | POTE ankyrin domain family member E | Uncharacterized protein | 0.422 |
| POTEF | DBNL | ENSP00000350052 | ENSP00000417653 | POTE ankyrin domain family, member F | drebrin-like; Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G- actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse [...] | 0.722 |
| POTEF | ENSG00000258555 | ENSP00000350052 | ENSP00000351480 | POTE ankyrin domain family, member F | Uncharacterized protein | 0.422 |
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