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STRINGSTRING
COIL COIL NEDD8 NEDD8 UBC UBC UBL5 UBL5 SART1 SART1 RBMX2 RBMX2 PRPF8 PRPF8 SNIP1 SNIP1 BUD13 BUD13 RBM22 RBM22 CDC40 CDC40
"UBL5" - ubiquitin-like 5 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
UBL5ubiquitin-like 5 (73 aa)    
Predicted Functional Partners:
SART1
squamous cell carcinoma antigen recognized by T cells; Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA (800 aa)
        score_image   score_image   0.999
PRPF8
PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae); Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5’ and the 3’ splice site (2335 aa)
        score_image   score_image   0.956
RBMX2
RNA binding motif protein, X-linked 2 (322 aa)
      score_image score_image       0.952
BUD13
BUD13 homolog (S. cerevisiae) (619 aa)
      score_image score_image       0.951
CDC40
cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing (579 aa)
        score_image       0.950
SNIP1
Smad nuclear interacting protein 1; Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3’end of the CCND1 gene and its mRNA (396 aa)
        score_image       0.950
RBM22
RNA binding motif protein 22; Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5’ splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses (420 aa)
        score_image       0.950
NEDD8
neural precursor cell expressed, developmentally down-regulated 8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C- APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (81 aa)
      score_image     score_image   0.918
COIL
coilin; Is a component of the nuclear coiled bodies (CBS) which are involved in the function or assembly/disassembly of nucleoplasmic snRNPs. During mitosis, CBS disassemble, coinciding with a mitotic-specific phosphorylation of p80 coilin (576 aa)
        score_image   score_image   0.918
UBC
ubiquitin C (685 aa)
      score_image score_image   score_image   0.875
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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