| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CAD | HELZ | ENSP00000264705 | ENSP00000351524 | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | helicase with zinc finger; May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo | 0.706 |
| CAD | UBC | ENSP00000264705 | ENSP00000344818 | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | ubiquitin C | 0.874 |
| HELZ | CAD | ENSP00000351524 | ENSP00000264705 | helicase with zinc finger; May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | 0.706 |
| HELZ | MRPS18A | ENSP00000351524 | ENSP00000361206 | helicase with zinc finger; May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo | mitochondrial ribosomal protein S18A | 0.604 |
| HELZ | NCBP2 | ENSP00000351524 | ENSP00000326806 | helicase with zinc finger; May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo | nuclear cap binding protein subunit 2, 20kDa; Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5’ cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5’ end of mRNA and to mRNA export in a 5’ to 3’ direction through the nuclear pore. [...] | 0.598 |
| HELZ | NCOR1 | ENSP00000351524 | ENSP00000268712 | helicase with zinc finger; May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo | nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors | 0.608 |
| HELZ | NKX2-8 | ENSP00000351524 | ENSP00000258829 | helicase with zinc finger; May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo | NK2 homeobox 8 | 0.860 |
| HELZ | RARA | ENSP00000351524 | ENSP00000254066 | helicase with zinc finger; May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo | retinoic acid receptor, alpha; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5’-AGGTCA-3’ sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcrip [...] | 0.623 |
| HELZ | RBM22 | ENSP00000351524 | ENSP00000199814 | helicase with zinc finger; May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo | RNA binding motif protein 22; Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5’ splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses | 0.577 |
| HELZ | SMYD3 | ENSP00000351524 | ENSP00000373637 | helicase with zinc finger; May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo | SET and MYND domain containing 3; Histone methyltransferase. Specifically methylates ’Lys- 4’ and ’Lys-5’ of histone H3, inducing di- and tri-methylation, but not monomethylation. Plays an important role in transcriptional activation as a member of an RNA polymerase complex. Binds DNA containing 5’-CCCTCC-3’ or 5’-GAGGGG-3’ sequences | 0.936 |
| HELZ | UBC | ENSP00000351524 | ENSP00000344818 | helicase with zinc finger; May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo | ubiquitin C | 0.858 |
| HELZ | ZBTB16 | ENSP00000351524 | ENSP00000338157 | helicase with zinc finger; May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo | zinc finger and BTB domain containing 16; Probable transcription factor. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins | 0.731 |
| MRPS18A | HELZ | ENSP00000361206 | ENSP00000351524 | mitochondrial ribosomal protein S18A | helicase with zinc finger; May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo | 0.604 |
| MRPS18A | UBC | ENSP00000361206 | ENSP00000344818 | mitochondrial ribosomal protein S18A | ubiquitin C | 0.483 |
| NCBP2 | HELZ | ENSP00000326806 | ENSP00000351524 | nuclear cap binding protein subunit 2, 20kDa; Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5’ cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5’ end of mRNA and to mRNA export in a 5’ to 3’ direction through the nuclear pore. [...] | helicase with zinc finger; May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo | 0.598 |
| NCBP2 | RBM22 | ENSP00000326806 | ENSP00000199814 | nuclear cap binding protein subunit 2, 20kDa; Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5’ cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5’ end of mRNA and to mRNA export in a 5’ to 3’ direction through the nuclear pore. [...] | RNA binding motif protein 22; Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5’ splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses | 0.668 |
| NCBP2 | UBC | ENSP00000326806 | ENSP00000344818 | nuclear cap binding protein subunit 2, 20kDa; Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5’ cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5’ end of mRNA and to mRNA export in a 5’ to 3’ direction through the nuclear pore. [...] | ubiquitin C | 0.862 |
| NCOR1 | HELZ | ENSP00000268712 | ENSP00000351524 | nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors | helicase with zinc finger; May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo | 0.608 |
| NCOR1 | RARA | ENSP00000268712 | ENSP00000254066 | nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors | retinoic acid receptor, alpha; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5’-AGGTCA-3’ sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcrip [...] | 0.999 |
| NCOR1 | UBC | ENSP00000268712 | ENSP00000344818 | nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors | ubiquitin C | 0.992 |
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