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STRINGSTRING
CNTNAP2 CNTNAP2 PTCHD1 PTCHD1 SHANK3 SHANK3 NRXN1 NRXN1 DLG2 DLG2 NLGN3 NLGN3 NRXN3 NRXN3 DLG4 DLG4 DLG3 DLG3 MMEL1 MMEL1 NRXN2 NRXN2
"NLGN3" - neuroligin 3 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Cooccurence
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[Homology]
Score
NLGN3neuroligin 3 (848 aa)    
Predicted Functional Partners:
NRXN1
neurexin 1; Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis (By similarity) (1547 aa)
        score_image score_image score_image   0.995
NRXN2
neurexin 2; Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling (1712 aa)
        score_image score_image score_image   0.980
NRXN3
neurexin 3; Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May play a role in angiogenesis (By similarity) (1061 aa)
        score_image   score_image   0.886
SHANK3
SH3 and multiple ankyrin repeat domains 3; Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction (1747 aa)
            score_image   0.797
DLG4
discs, large homolog 4 (Drosophila); Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity) (767 aa)
        score_image   score_image   0.776
MMEL1
membrane metallo-endopeptidase-like 1; Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificity with MME and cleaves peptides at the same amide bond (By similarity) (779 aa)
            score_image   0.755
DLG3
discs, large homolog 3 (Drosophila); Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling (817 aa)
        score_image   score_image   0.724
CNTNAP2
contactin associated protein-like 2; May play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparanodal region of the axo-glial junction (1331 aa)
            score_image   0.635
DLG2
discs, large homolog 2 (Drosophila); Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity) (975 aa)
        score_image   score_image   0.635
PTCHD1
patched domain containing 1 (888 aa)
            score_image   0.632
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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