SMTN protein (Homo sapiens) - STRING network view

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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protein of unknown 3D structure

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some 3D structure is known or predicted

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query proteins and first shell of interactors

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second shell of interactors

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

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Predicted Interactions

gene neighborhood

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[Homology]

Score

SMTN

smoothelin (940 aa)

Predicted Functional Partners:

MIS12

0.985

ZWINT

0.985

SRF

0.896

TAGLN

0.793

ACTA1

0.793

MYH11

0.763

MYH14

0.709

UBC

0.670

CNN1

0.656

MYOCD

0.646

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTA1	CNN1	ENSP00000355645	ENSP00000252456	actin, alpha 1, skeletal muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells	calponin 1, basic, smooth muscle; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity)	0.920
ACTA1	MYH11	ENSP00000355645	ENSP00000379616	actin, alpha 1, skeletal muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells	myosin, heavy chain 11, smooth muscle; Muscle contraction	0.809
ACTA1	MYH14	ENSP00000355645	ENSP00000262269	actin, alpha 1, skeletal muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells	myosin, heavy chain 14, non-muscle	0.815
ACTA1	SMTN	ENSP00000355645	ENSP00000351593	actin, alpha 1, skeletal muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells	smoothelin	0.793
ACTA1	SRF	ENSP00000355645	ENSP00000265354	actin, alpha 1, skeletal muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells	serum response factor (c-fos serum response element-binding transcription factor); SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5’ of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation	0.744
ACTA1	TAGLN	ENSP00000355645	ENSP00000278968	actin, alpha 1, skeletal muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells	transgelin; Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence	0.816
ACTA1	UBC	ENSP00000355645	ENSP00000344818	actin, alpha 1, skeletal muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells	ubiquitin C	0.999
CNN1	ACTA1	ENSP00000252456	ENSP00000355645	calponin 1, basic, smooth muscle; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity)	actin, alpha 1, skeletal muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells	0.920
CNN1	MYH11	ENSP00000252456	ENSP00000379616	calponin 1, basic, smooth muscle; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity)	myosin, heavy chain 11, smooth muscle; Muscle contraction	0.668
CNN1	MYH14	ENSP00000252456	ENSP00000262269	calponin 1, basic, smooth muscle; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity)	myosin, heavy chain 14, non-muscle	0.481
CNN1	MYOCD	ENSP00000252456	ENSP00000401678	calponin 1, basic, smooth muscle; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity)	myocardin; Smooth muscle cells (SM) and cardiac muscle cells- specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity)	0.561
CNN1	SMTN	ENSP00000252456	ENSP00000351593	calponin 1, basic, smooth muscle; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity)	smoothelin	0.656
MIS12	SMTN	ENSP00000370557	ENSP00000351593	MIS12, MIND kinetochore complex component, homolog (S. pombe); Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis	smoothelin	0.985
MIS12	ZWINT	ENSP00000370557	ENSP00000363055	MIS12, MIND kinetochore complex component, homolog (S. pombe); Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis	ZW10 interactor; Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase	0.999
MYH11	ACTA1	ENSP00000379616	ENSP00000355645	myosin, heavy chain 11, smooth muscle; Muscle contraction	actin, alpha 1, skeletal muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells	0.809
MYH11	CNN1	ENSP00000379616	ENSP00000252456	myosin, heavy chain 11, smooth muscle; Muscle contraction	calponin 1, basic, smooth muscle; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity)	0.668
MYH11	MYH14	ENSP00000379616	ENSP00000262269	myosin, heavy chain 11, smooth muscle; Muscle contraction	myosin, heavy chain 14, non-muscle	0.902
MYH11	MYOCD	ENSP00000379616	ENSP00000401678	myosin, heavy chain 11, smooth muscle; Muscle contraction	myocardin; Smooth muscle cells (SM) and cardiac muscle cells- specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity)	0.725
MYH11	SMTN	ENSP00000379616	ENSP00000351593	myosin, heavy chain 11, smooth muscle; Muscle contraction	smoothelin	0.763
MYH11	SRF	ENSP00000379616	ENSP00000265354	myosin, heavy chain 11, smooth muscle; Muscle contraction	serum response factor (c-fos serum response element-binding transcription factor); SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5’ of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation	0.678

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