PRRT2 protein (Homo sapiens) - STRING network view

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PRRT2

proline-rich transmembrane protein 2 (340 aa)

Predicted Functional Partners:

ABCC11

0.861

ABCC12

0.861

PNKD

0.756

CAMP

0.751

ABCG4

0.681

PRRT3

0.650

ABCC5

0.606

SATB1

0.576

NFE2L2

0.576

STXBP1

0.576

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCC11	ABCG4	ENSP00000349017	ENSP00000304111	ATP-binding cassette, sub-family C (CFTR/MRP), member 11; Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides. Enhances the cellular extrusion of cAMP and cGMP. Stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycochola [...]	ATP-binding cassette, sub-family G (WHITE), member 4; May be involved in macrophage lipid homeostasis	0.931
ABCC11	PRRT2	ENSP00000349017	ENSP00000351608	ATP-binding cassette, sub-family C (CFTR/MRP), member 11; Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides. Enhances the cellular extrusion of cAMP and cGMP. Stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycochola [...]	proline-rich transmembrane protein 2	0.861
ABCC12	ABCG4	ENSP00000311030	ENSP00000304111	ATP-binding cassette, sub-family C (CFTR/MRP), member 12; Probable transporter (By similarity)	ATP-binding cassette, sub-family G (WHITE), member 4; May be involved in macrophage lipid homeostasis	0.422
ABCC12	PRRT2	ENSP00000311030	ENSP00000351608	ATP-binding cassette, sub-family C (CFTR/MRP), member 12; Probable transporter (By similarity)	proline-rich transmembrane protein 2	0.861
ABCC5	ABCG4	ENSP00000333926	ENSP00000304111	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	ATP-binding cassette, sub-family G (WHITE), member 4; May be involved in macrophage lipid homeostasis	0.906
ABCC5	PRRT2	ENSP00000333926	ENSP00000351608	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	proline-rich transmembrane protein 2	0.606
ABCG4	ABCC11	ENSP00000304111	ENSP00000349017	ATP-binding cassette, sub-family G (WHITE), member 4; May be involved in macrophage lipid homeostasis	ATP-binding cassette, sub-family C (CFTR/MRP), member 11; Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides. Enhances the cellular extrusion of cAMP and cGMP. Stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycochola [...]	0.931
ABCG4	ABCC12	ENSP00000304111	ENSP00000311030	ATP-binding cassette, sub-family G (WHITE), member 4; May be involved in macrophage lipid homeostasis	ATP-binding cassette, sub-family C (CFTR/MRP), member 12; Probable transporter (By similarity)	0.422
ABCG4	ABCC5	ENSP00000304111	ENSP00000333926	ATP-binding cassette, sub-family G (WHITE), member 4; May be involved in macrophage lipid homeostasis	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	0.906
ABCG4	PRRT2	ENSP00000304111	ENSP00000351608	ATP-binding cassette, sub-family G (WHITE), member 4; May be involved in macrophage lipid homeostasis	proline-rich transmembrane protein 2	0.681
CAMP	PRRT2	ENSP00000458149	ENSP00000351608	cathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity	proline-rich transmembrane protein 2	0.751
NFE2L2	PRRT2	ENSP00000380252	ENSP00000351608	nuclear factor (erythroid-derived 2)-like 2; Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region	proline-rich transmembrane protein 2	0.576
PNKD	PRRT2	ENSP00000273077	ENSP00000351608	paroxysmal nonkinesigenic dyskinesia; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway (By similarity)	proline-rich transmembrane protein 2	0.756
PRRT2	ABCC11	ENSP00000351608	ENSP00000349017	proline-rich transmembrane protein 2	ATP-binding cassette, sub-family C (CFTR/MRP), member 11; Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides. Enhances the cellular extrusion of cAMP and cGMP. Stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycochola [...]	0.861
PRRT2	ABCC12	ENSP00000351608	ENSP00000311030	proline-rich transmembrane protein 2	ATP-binding cassette, sub-family C (CFTR/MRP), member 12; Probable transporter (By similarity)	0.861
PRRT2	ABCC5	ENSP00000351608	ENSP00000333926	proline-rich transmembrane protein 2	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	0.606
PRRT2	ABCG4	ENSP00000351608	ENSP00000304111	proline-rich transmembrane protein 2	ATP-binding cassette, sub-family G (WHITE), member 4; May be involved in macrophage lipid homeostasis	0.681
PRRT2	CAMP	ENSP00000351608	ENSP00000458149	proline-rich transmembrane protein 2	cathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity	0.751
PRRT2	NFE2L2	ENSP00000351608	ENSP00000380252	proline-rich transmembrane protein 2	nuclear factor (erythroid-derived 2)-like 2; Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region	0.576
PRRT2	PNKD	ENSP00000351608	ENSP00000273077	proline-rich transmembrane protein 2	paroxysmal nonkinesigenic dyskinesia; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway (By similarity)	0.756

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