node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATXN1 | ATXN1L | ENSP00000244769 | ENSP00000415822 | ataxin 1; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. The expansion of the polyglutamine tract may alter this function | ataxin 1-like; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1) (By similarity) | 0.707 |
ATXN1 | FAM76B | ENSP00000244769 | ENSP00000351631 | ataxin 1; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. The expansion of the polyglutamine tract may alter this function | family with sequence similarity 76, member B | 0.552 |
ATXN1 | KIAA0556 | ENSP00000244769 | ENSP00000261588 | ataxin 1; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. The expansion of the polyglutamine tract may alter this function | KIAA0556 | 0.485 |
ATXN1L | ATXN1 | ENSP00000415822 | ENSP00000244769 | ataxin 1-like; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1) (By similarity) | ataxin 1; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. The expansion of the polyglutamine tract may alter this function | 0.707 |
ATXN1L | FAM76B | ENSP00000415822 | ENSP00000351631 | ataxin 1-like; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1) (By similarity) | family with sequence similarity 76, member B | 0.552 |
ATXN1L | KIAA0556 | ENSP00000415822 | ENSP00000261588 | ataxin 1-like; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1) (By similarity) | KIAA0556 | 0.485 |
FAM76B | ATXN1 | ENSP00000351631 | ENSP00000244769 | family with sequence similarity 76, member B | ataxin 1; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. The expansion of the polyglutamine tract may alter this function | 0.552 |
FAM76B | ATXN1L | ENSP00000351631 | ENSP00000415822 | family with sequence similarity 76, member B | ataxin 1-like; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1) (By similarity) | 0.552 |
FAM76B | KIAA0556 | ENSP00000351631 | ENSP00000261588 | family with sequence similarity 76, member B | KIAA0556 | 0.485 |
FAM76B | KIAA1429 | ENSP00000351631 | ENSP00000297591 | family with sequence similarity 76, member B | KIAA1429 | 0.663 |
FAM76B | KRTAP10-11 | ENSP00000351631 | ENSP00000334197 | family with sequence similarity 76, member B | keratin associated protein 10-11; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins | 0.447 |
FAM76B | KRTAP4-7 | ENSP00000351631 | ENSP00000375236 | family with sequence similarity 76, member B | keratin associated protein 4-7; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins | 0.760 |
FAM76B | SRPK1 | ENSP00000351631 | ENSP00000362931 | family with sequence similarity 76, member B | SRSF protein kinase 1; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activiti [...] | 0.461 |
FAM76B | SRPK2 | ENSP00000351631 | ENSP00000377262 | family with sequence similarity 76, member B | SRSF protein kinase 2; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and [...] | 0.461 |
FAM76B | ZNF24 | ENSP00000351631 | ENSP00000261332 | family with sequence similarity 76, member B | zinc finger protein 24; Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5’-TCAT-3’ DNA sequence (By similarity). Has transcription repressor activity in vitro | 0.504 |
FAM76B | ZNF396 | ENSP00000351631 | ENSP00000302310 | family with sequence similarity 76, member B | zinc finger protein 396; Isoform 1 and isoform 2 act as DNA-dependent transcriptional repressors | 0.435 |
KIAA0556 | ATXN1 | ENSP00000261588 | ENSP00000244769 | KIAA0556 | ataxin 1; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. The expansion of the polyglutamine tract may alter this function | 0.485 |
KIAA0556 | ATXN1L | ENSP00000261588 | ENSP00000415822 | KIAA0556 | ataxin 1-like; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1) (By similarity) | 0.485 |
KIAA0556 | FAM76B | ENSP00000261588 | ENSP00000351631 | KIAA0556 | family with sequence similarity 76, member B | 0.485 |
KIAA1429 | FAM76B | ENSP00000297591 | ENSP00000351631 | KIAA1429 | family with sequence similarity 76, member B | 0.663 |