node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EHD1 | IMPACT | ENSP00000320516 | ENSP00000284202 | EH-domain containing 1; Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes | Impact homolog (mouse); Translational regulator that ensures constant high levels of translation under amino acid starvation. Acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis (By similarity) | 0.418 |
EHD1 | MICAL1 | ENSP00000320516 | ENSP00000351664 | EH-domain containing 1; Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes | microtubule associated monoxygenase, calponin and LIM domain containing 1 | 0.717 |
EHD1 | UBC | ENSP00000320516 | ENSP00000344818 | EH-domain containing 1; Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes | ubiquitin C | 0.812 |
GRB2 | MICAL1 | ENSP00000339007 | ENSP00000351664 | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | microtubule associated monoxygenase, calponin and LIM domain containing 1 | 0.601 |
GRB2 | NEDD9 | ENSP00000339007 | ENSP00000368759 | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | neural precursor cell expressed, developmentally down-regulated 9; Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK [...] | 0.834 |
GRB2 | SRC | ENSP00000339007 | ENSP00000350941 | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein- coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to f [...] | 0.996 |
GRB2 | UBC | ENSP00000339007 | ENSP00000344818 | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | ubiquitin C | 0.949 |
IMPACT | EHD1 | ENSP00000284202 | ENSP00000320516 | Impact homolog (mouse); Translational regulator that ensures constant high levels of translation under amino acid starvation. Acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis (By similarity) | EH-domain containing 1; Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes | 0.418 |
IMPACT | MICAL1 | ENSP00000284202 | ENSP00000351664 | Impact homolog (mouse); Translational regulator that ensures constant high levels of translation under amino acid starvation. Acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis (By similarity) | microtubule associated monoxygenase, calponin and LIM domain containing 1 | 0.608 |
IMPACT | UBC | ENSP00000284202 | ENSP00000344818 | Impact homolog (mouse); Translational regulator that ensures constant high levels of translation under amino acid starvation. Acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis (By similarity) | ubiquitin C | 0.695 |
MICAL1 | EHD1 | ENSP00000351664 | ENSP00000320516 | microtubule associated monoxygenase, calponin and LIM domain containing 1 | EH-domain containing 1; Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes | 0.717 |
MICAL1 | GRB2 | ENSP00000351664 | ENSP00000339007 | microtubule associated monoxygenase, calponin and LIM domain containing 1 | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | 0.601 |
MICAL1 | IMPACT | ENSP00000351664 | ENSP00000284202 | microtubule associated monoxygenase, calponin and LIM domain containing 1 | Impact homolog (mouse); Translational regulator that ensures constant high levels of translation under amino acid starvation. Acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis (By similarity) | 0.608 |
MICAL1 | NEDD9 | ENSP00000351664 | ENSP00000368759 | microtubule associated monoxygenase, calponin and LIM domain containing 1 | neural precursor cell expressed, developmentally down-regulated 9; Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK [...] | 0.846 |
MICAL1 | RAB1A | ENSP00000351664 | ENSP00000387286 | microtubule associated monoxygenase, calponin and LIM domain containing 1 | RAB1A, member RAS oncogene family; Probably required for transit of protein from the ER through Golgi compartment. Binds GTP and GDP and possesses intrinsic GTPase activity | 0.674 |
MICAL1 | RAB1B | ENSP00000351664 | ENSP00000310226 | microtubule associated monoxygenase, calponin and LIM domain containing 1 | RAB1B, member RAS oncogene family; Protein transport. Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments | 0.598 |
MICAL1 | RHOBTB2 | ENSP00000351664 | ENSP00000427926 | microtubule associated monoxygenase, calponin and LIM domain containing 1 | Rho-related BTB domain containing 2 | 0.594 |
MICAL1 | SRC | ENSP00000351664 | ENSP00000350941 | microtubule associated monoxygenase, calponin and LIM domain containing 1 | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein- coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to f [...] | 0.612 |
MICAL1 | UBC | ENSP00000351664 | ENSP00000344818 | microtubule associated monoxygenase, calponin and LIM domain containing 1 | ubiquitin C | 0.753 |
MICAL1 | WRNIP1 | ENSP00000351664 | ENSP00000370150 | microtubule associated monoxygenase, calponin and LIM domain containing 1 | Werner helicase interacting protein 1 | 0.590 |