node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AMPH | DNM2 | ENSP00000348602 | ENSP00000347890 | amphiphysin; May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton | dynamin 2; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis | 0.999 |
AMPH | MANEA | ENSP00000348602 | ENSP00000351669 | amphiphysin; May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton | mannosidase, endo-alpha | 0.564 |
DNM2 | AMPH | ENSP00000347890 | ENSP00000348602 | dynamin 2; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis | amphiphysin; May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton | 0.999 |
DNM2 | MANEA | ENSP00000347890 | ENSP00000351669 | dynamin 2; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis | mannosidase, endo-alpha | 0.567 |
FBXO9 | MANEA | ENSP00000244426 | ENSP00000351669 | F-box protein 9; Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is ina [...] | mannosidase, endo-alpha | 0.536 |
FBXO9 | PRR15L | ENSP00000244426 | ENSP00000300557 | F-box protein 9; Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is ina [...] | proline rich 15-like | 0.612 |
FTH1 | MANEA | ENSP00000273550 | ENSP00000351669 | ferritin, heavy polypeptide 1; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity) | mannosidase, endo-alpha | 0.624 |
MAN1B1 | MANEA | ENSP00000360645 | ENSP00000351669 | mannosidase, alpha, class 1B, member 1; Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2) | mannosidase, endo-alpha | 0.889 |
MAN2B1 | MANEA | ENSP00000395473 | ENSP00000351669 | mannosidase, alpha, class 2B, member 1; Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. Cleaves all known types of alpha-mannosidic linkages | mannosidase, endo-alpha | 0.566 |
MANEA | AMPH | ENSP00000351669 | ENSP00000348602 | mannosidase, endo-alpha | amphiphysin; May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton | 0.564 |
MANEA | DNM2 | ENSP00000351669 | ENSP00000347890 | mannosidase, endo-alpha | dynamin 2; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis | 0.567 |
MANEA | FBXO9 | ENSP00000351669 | ENSP00000244426 | mannosidase, endo-alpha | F-box protein 9; Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is ina [...] | 0.536 |
MANEA | FTH1 | ENSP00000351669 | ENSP00000273550 | mannosidase, endo-alpha | ferritin, heavy polypeptide 1; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity) | 0.624 |
MANEA | MAN1B1 | ENSP00000351669 | ENSP00000360645 | mannosidase, endo-alpha | mannosidase, alpha, class 1B, member 1; Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2) | 0.889 |
MANEA | MAN2B1 | ENSP00000351669 | ENSP00000395473 | mannosidase, endo-alpha | mannosidase, alpha, class 2B, member 1; Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. Cleaves all known types of alpha-mannosidic linkages | 0.566 |
MANEA | NIPSNAP3A | ENSP00000351669 | ENSP00000363899 | mannosidase, endo-alpha | nipsnap homolog 3A (C. elegans) | 0.502 |
MANEA | PEPD | ENSP00000351669 | ENSP00000244137 | mannosidase, endo-alpha | peptidase D | 0.564 |
MANEA | PRR15L | ENSP00000351669 | ENSP00000300557 | mannosidase, endo-alpha | proline rich 15-like | 0.521 |
MANEA | SLITRK1 | ENSP00000351669 | ENSP00000366288 | mannosidase, endo-alpha | SLIT and NTRK-like family, member 1; Enhances neuronal dendrite outgrowth | 0.504 |
NIPSNAP3A | MANEA | ENSP00000363899 | ENSP00000351669 | nipsnap homolog 3A (C. elegans) | mannosidase, endo-alpha | 0.502 |