ZSCAN5B protein (Homo sapiens) - STRING network view

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ZSCAN5B

zinc finger and SCAN domain containing 5B; May be involved in transcriptional regulation (By similarity) (495 aa)

Predicted Functional Partners:

HERC4

0.562

XRN1

0.543

STOX1

0.502

KDM2A

0.501

FBXL19

0.501

KDM2B

0.501

NLRP8

0.499

PTPN23

0.476

NLRP5

0.472

PBLD

0.472

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FBXL19	ZSCAN5B	ENSP00000369666	ENSP00000351883	F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity)	zinc finger and SCAN domain containing 5B; May be involved in transcriptional regulation (By similarity)	0.501
HERC4	PBLD	ENSP00000378624	ENSP00000308466	HECT and RLD domain containing E3 ubiquitin protein ligase 4; Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates (By similarity)	phenazine biosynthesis-like protein domain containing	0.407
HERC4	ZSCAN5B	ENSP00000378624	ENSP00000351883	HECT and RLD domain containing E3 ubiquitin protein ligase 4; Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates (By similarity)	zinc finger and SCAN domain containing 5B; May be involved in transcriptional regulation (By similarity)	0.562
KDM2A	ZSCAN5B	ENSP00000432786	ENSP00000351883	lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...]	zinc finger and SCAN domain containing 5B; May be involved in transcriptional regulation (By similarity)	0.501
KDM2B	ZSCAN5B	ENSP00000366271	ENSP00000351883	lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...]	zinc finger and SCAN domain containing 5B; May be involved in transcriptional regulation (By similarity)	0.501
NLRP5	ZSCAN5B	ENSP00000375063	ENSP00000351883	NLR family, pyrin domain containing 5; As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions (By similarity)	zinc finger and SCAN domain containing 5B; May be involved in transcriptional regulation (By similarity)	0.472
NLRP8	ZSCAN5B	ENSP00000291971	ENSP00000351883	NLR family, pyrin domain containing 8; Involved in inflammation (Potential)	zinc finger and SCAN domain containing 5B; May be involved in transcriptional regulation (By similarity)	0.499
PBLD	HERC4	ENSP00000308466	ENSP00000378624	phenazine biosynthesis-like protein domain containing	HECT and RLD domain containing E3 ubiquitin protein ligase 4; Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates (By similarity)	0.407
PBLD	ZSCAN5B	ENSP00000308466	ENSP00000351883	phenazine biosynthesis-like protein domain containing	zinc finger and SCAN domain containing 5B; May be involved in transcriptional regulation (By similarity)	0.472
PTPN23	ZSCAN5B	ENSP00000265562	ENSP00000351883	protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis	zinc finger and SCAN domain containing 5B; May be involved in transcriptional regulation (By similarity)	0.476
STOX1	ZSCAN5B	ENSP00000298596	ENSP00000351883	storkhead box 1	zinc finger and SCAN domain containing 5B; May be involved in transcriptional regulation (By similarity)	0.502
XRN1	ZSCAN5B	ENSP00000264951	ENSP00000351883	5’-3’ exoribonuclease 1; Major 5’-3’ exoribonuclease involved in mRNA decay. Required for the 5’-3’-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS)	zinc finger and SCAN domain containing 5B; May be involved in transcriptional regulation (By similarity)	0.543
ZSCAN5B	FBXL19	ENSP00000351883	ENSP00000369666	zinc finger and SCAN domain containing 5B; May be involved in transcriptional regulation (By similarity)	F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity)	0.501
ZSCAN5B	HERC4	ENSP00000351883	ENSP00000378624	zinc finger and SCAN domain containing 5B; May be involved in transcriptional regulation (By similarity)	HECT and RLD domain containing E3 ubiquitin protein ligase 4; Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates (By similarity)	0.562
ZSCAN5B	KDM2A	ENSP00000351883	ENSP00000432786	zinc finger and SCAN domain containing 5B; May be involved in transcriptional regulation (By similarity)	lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...]	0.501
ZSCAN5B	KDM2B	ENSP00000351883	ENSP00000366271	zinc finger and SCAN domain containing 5B; May be involved in transcriptional regulation (By similarity)	lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...]	0.501
ZSCAN5B	NLRP5	ENSP00000351883	ENSP00000375063	zinc finger and SCAN domain containing 5B; May be involved in transcriptional regulation (By similarity)	NLR family, pyrin domain containing 5; As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions (By similarity)	0.472
ZSCAN5B	NLRP8	ENSP00000351883	ENSP00000291971	zinc finger and SCAN domain containing 5B; May be involved in transcriptional regulation (By similarity)	NLR family, pyrin domain containing 8; Involved in inflammation (Potential)	0.499
ZSCAN5B	PBLD	ENSP00000351883	ENSP00000308466	zinc finger and SCAN domain containing 5B; May be involved in transcriptional regulation (By similarity)	phenazine biosynthesis-like protein domain containing	0.472
ZSCAN5B	PTPN23	ENSP00000351883	ENSP00000265562	zinc finger and SCAN domain containing 5B; May be involved in transcriptional regulation (By similarity)	protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis	0.476

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