node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
RASSF2 | SPANXC | ENSP00000368684 | ENSP00000351884 | Ras association (RalGDS/AF-6) domain family member 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation | SPANX family, member C | 0.495 |
RASSF2 | STK3 | ENSP00000368684 | ENSP00000390500 | Ras association (RalGDS/AF-6) domain family member 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation | serine/threonine kinase 3; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, wh [...] | 0.997 |
RASSF2 | STK4 | ENSP00000368684 | ENSP00000361892 | Ras association (RalGDS/AF-6) domain family member 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation | serine/threonine kinase 4; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, wh [...] | 0.999 |
RASSF4 | SPANXC | ENSP00000339692 | ENSP00000351884 | Ras association (RalGDS/AF-6) domain family member 4; Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest | SPANX family, member C | 0.495 |
RASSF4 | STK3 | ENSP00000339692 | ENSP00000390500 | Ras association (RalGDS/AF-6) domain family member 4; Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest | serine/threonine kinase 3; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, wh [...] | 0.985 |
RASSF4 | STK4 | ENSP00000339692 | ENSP00000361892 | Ras association (RalGDS/AF-6) domain family member 4; Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest | serine/threonine kinase 4; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, wh [...] | 0.999 |
SETBP1 | SPANXC | ENSP00000282030 | ENSP00000351884 | SET binding protein 1 | SPANX family, member C | 0.571 |
SPANXC | RASSF2 | ENSP00000351884 | ENSP00000368684 | SPANX family, member C | Ras association (RalGDS/AF-6) domain family member 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation | 0.495 |
SPANXC | RASSF4 | ENSP00000351884 | ENSP00000339692 | SPANX family, member C | Ras association (RalGDS/AF-6) domain family member 4; Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest | 0.495 |
SPANXC | SETBP1 | ENSP00000351884 | ENSP00000282030 | SPANX family, member C | SET binding protein 1 | 0.571 |
SPANXC | STK3 | ENSP00000351884 | ENSP00000390500 | SPANX family, member C | serine/threonine kinase 3; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, wh [...] | 0.495 |
SPANXC | STK4 | ENSP00000351884 | ENSP00000361892 | SPANX family, member C | serine/threonine kinase 4; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, wh [...] | 0.495 |
SPANXC | TRPV4 | ENSP00000351884 | ENSP00000261740 | SPANX family, member C | transient receptor potential cation channel, subfamily V, member 4 | 0.576 |
STK3 | RASSF2 | ENSP00000390500 | ENSP00000368684 | serine/threonine kinase 3; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, wh [...] | Ras association (RalGDS/AF-6) domain family member 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation | 0.997 |
STK3 | RASSF4 | ENSP00000390500 | ENSP00000339692 | serine/threonine kinase 3; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, wh [...] | Ras association (RalGDS/AF-6) domain family member 4; Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest | 0.985 |
STK3 | SPANXC | ENSP00000390500 | ENSP00000351884 | serine/threonine kinase 3; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, wh [...] | SPANX family, member C | 0.495 |
STK3 | STK4 | ENSP00000390500 | ENSP00000361892 | serine/threonine kinase 3; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, wh [...] | serine/threonine kinase 4; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, wh [...] | 0.996 |
STK4 | RASSF2 | ENSP00000361892 | ENSP00000368684 | serine/threonine kinase 4; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, wh [...] | Ras association (RalGDS/AF-6) domain family member 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation | 0.999 |
STK4 | RASSF4 | ENSP00000361892 | ENSP00000339692 | serine/threonine kinase 4; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, wh [...] | Ras association (RalGDS/AF-6) domain family member 4; Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest | 0.999 |
STK4 | SPANXC | ENSP00000361892 | ENSP00000351884 | serine/threonine kinase 4; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, wh [...] | SPANX family, member C | 0.495 |