| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABCA1 | GULP1 | ENSP00000363868 | ENSP00000352047 | ATP-binding cassette, sub-family A (ABC1), member 1 | GULP, engulfment adaptor PTB domain containing 1 | 0.872 |
| ABCA1 | LRP1 | ENSP00000363868 | ENSP00000243077 | ATP-binding cassette, sub-family A (ABC1), member 1 | low density lipoprotein receptor-related protein 1; Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission | 0.878 |
| ABCA1 | MEGF10 | ENSP00000363868 | ENSP00000274473 | ATP-binding cassette, sub-family A (ABC1), member 1 | multiple EGF-like-domains 10; Membrane receptor involved in phagocytosis by macrophages of apoptotic cells. Cooperates with ABCA1 within the process of engulfment. Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides. May also function in the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements. May pl [...] | 0.438 |
| ACAP1 | ARF6 | ENSP00000158762 | ENSP00000298316 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 1; GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface | ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May modulate vesicle budding and uncoating within the Golgi apparatus. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in the regulation of dendritic spine development (By similarity). Contributes to the regulation of dendritic branching and filopodia extension | 0.992 |
| ACAP1 | GULP1 | ENSP00000158762 | ENSP00000352047 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 1; GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface | GULP, engulfment adaptor PTB domain containing 1 | 0.915 |
| ARF6 | ACAP1 | ENSP00000298316 | ENSP00000158762 | ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May modulate vesicle budding and uncoating within the Golgi apparatus. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in the regulation of dendritic spine development (By similarity). Contributes to the regulation of dendritic branching and filopodia extension | ArfGAP with coiled-coil, ankyrin repeat and PH domains 1; GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface | 0.992 |
| ARF6 | GULP1 | ENSP00000298316 | ENSP00000352047 | ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May modulate vesicle budding and uncoating within the Golgi apparatus. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in the regulation of dendritic spine development (By similarity). Contributes to the regulation of dendritic branching and filopodia extension | GULP, engulfment adaptor PTB domain containing 1 | 0.984 |
| GREM2 | GULP1 | ENSP00000318650 | ENSP00000352047 | gremlin 2; Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner. Antagonized BMP4-induced suppression of progesterone production in granulosa cells (By similarity) | GULP, engulfment adaptor PTB domain containing 1 | 0.621 |
| GULP1 | ABCA1 | ENSP00000352047 | ENSP00000363868 | GULP, engulfment adaptor PTB domain containing 1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.872 |
| GULP1 | ACAP1 | ENSP00000352047 | ENSP00000158762 | GULP, engulfment adaptor PTB domain containing 1 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 1; GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface | 0.915 |
| GULP1 | ARF6 | ENSP00000352047 | ENSP00000298316 | GULP, engulfment adaptor PTB domain containing 1 | ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May modulate vesicle budding and uncoating within the Golgi apparatus. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in the regulation of dendritic spine development (By similarity). Contributes to the regulation of dendritic branching and filopodia extension | 0.984 |
| GULP1 | GREM2 | ENSP00000352047 | ENSP00000318650 | GULP, engulfment adaptor PTB domain containing 1 | gremlin 2; Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner. Antagonized BMP4-induced suppression of progesterone production in granulosa cells (By similarity) | 0.621 |
| GULP1 | IFT122 | ENSP00000352047 | ENSP00000296266 | GULP, engulfment adaptor PTB domain containing 1 | intraflagellar transport 122 homolog (Chlamydomonas); Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity) | 0.610 |
| GULP1 | LRP1 | ENSP00000352047 | ENSP00000243077 | GULP, engulfment adaptor PTB domain containing 1 | low density lipoprotein receptor-related protein 1; Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission | 0.783 |
| GULP1 | MEGF10 | ENSP00000352047 | ENSP00000274473 | GULP, engulfment adaptor PTB domain containing 1 | multiple EGF-like-domains 10; Membrane receptor involved in phagocytosis by macrophages of apoptotic cells. Cooperates with ABCA1 within the process of engulfment. Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides. May also function in the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements. May pl [...] | 0.975 |
| GULP1 | MEGF11 | ENSP00000352047 | ENSP00000386908 | GULP, engulfment adaptor PTB domain containing 1 | multiple EGF-like-domains 11; May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity) | 0.737 |
| GULP1 | MEGF6 | ENSP00000352047 | ENSP00000348982 | GULP, engulfment adaptor PTB domain containing 1 | multiple EGF-like-domains 6 | 0.737 |
| GULP1 | PEAR1 | ENSP00000352047 | ENSP00000292357 | GULP, engulfment adaptor PTB domain containing 1 | platelet endothelial aggregation receptor 1; When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells (By similarity) | 0.651 |
| IFT122 | GULP1 | ENSP00000296266 | ENSP00000352047 | intraflagellar transport 122 homolog (Chlamydomonas); Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity) | GULP, engulfment adaptor PTB domain containing 1 | 0.610 |
| IFT122 | MEGF10 | ENSP00000296266 | ENSP00000274473 | intraflagellar transport 122 homolog (Chlamydomonas); Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity) | multiple EGF-like-domains 10; Membrane receptor involved in phagocytosis by macrophages of apoptotic cells. Cooperates with ABCA1 within the process of engulfment. Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides. May also function in the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements. May pl [...] | 0.511 |
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