| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| HGS | SNX11 | ENSP00000331201 | ENSP00000352175 | hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down- regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | sorting nexin 11; May be involved in several stages of intracellular trafficking (By similarity) | 0.655 |
| HGS | SNX5 | ENSP00000331201 | ENSP00000366988 | hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down- regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | sorting nexin 5; May be involved in several stages of intracellular trafficking. Plays a role in macropinocytosis. Plays a role in the internalization of EGFR after EGF stimulation | 0.578 |
| HGS | VPS26A | ENSP00000331201 | ENSP00000263559 | hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down- regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | vacuolar protein sorting 26 homolog A (S. pombe); Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) | 0.602 |
| HGS | VPS26B | ENSP00000331201 | ENSP00000281187 | hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down- regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | vacuolar protein sorting 26 homolog B (S. pombe); Probable component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network (By similarity) | 0.403 |
| HGS | VPS29 | ENSP00000331201 | ENSP00000380795 | hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down- regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | vacuolar protein sorting 29 homolog (S. cerevisiae); Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro) | 0.420 |
| HGS | VPS35 | ENSP00000331201 | ENSP00000299138 | hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down- regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | vacuolar protein sorting 35 homolog (S. cerevisiae) | 0.851 |
| SNX11 | HGS | ENSP00000352175 | ENSP00000331201 | sorting nexin 11; May be involved in several stages of intracellular trafficking (By similarity) | hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down- regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | 0.655 |
| SNX11 | SNX32 | ENSP00000352175 | ENSP00000310620 | sorting nexin 11; May be involved in several stages of intracellular trafficking (By similarity) | sorting nexin 32; May be involved in several stages of intracellular trafficking (By similarity) | 0.658 |
| SNX11 | SNX5 | ENSP00000352175 | ENSP00000366988 | sorting nexin 11; May be involved in several stages of intracellular trafficking (By similarity) | sorting nexin 5; May be involved in several stages of intracellular trafficking. Plays a role in macropinocytosis. Plays a role in the internalization of EGFR after EGF stimulation | 0.697 |
| SNX11 | SNX6 | ENSP00000352175 | ENSP00000355217 | sorting nexin 11; May be involved in several stages of intracellular trafficking (By similarity) | sorting nexin 6; May be involved in several stages of intracellular trafficking. Promotes lysosomal degradation of CDKN1B (By similarity). Plays a role in retrograde protein transport from endosomes to the trans-Golgi network. May function as link between transport vesicles and dynactin. Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network. May contribute to transcription regulation | 0.681 |
| SNX11 | VPS26A | ENSP00000352175 | ENSP00000263559 | sorting nexin 11; May be involved in several stages of intracellular trafficking (By similarity) | vacuolar protein sorting 26 homolog A (S. pombe); Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) | 0.641 |
| SNX11 | VPS26B | ENSP00000352175 | ENSP00000281187 | sorting nexin 11; May be involved in several stages of intracellular trafficking (By similarity) | vacuolar protein sorting 26 homolog B (S. pombe); Probable component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network (By similarity) | 0.641 |
| SNX11 | VPS29 | ENSP00000352175 | ENSP00000380795 | sorting nexin 11; May be involved in several stages of intracellular trafficking (By similarity) | vacuolar protein sorting 29 homolog (S. cerevisiae); Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro) | 0.671 |
| SNX11 | VPS35 | ENSP00000352175 | ENSP00000299138 | sorting nexin 11; May be involved in several stages of intracellular trafficking (By similarity) | vacuolar protein sorting 35 homolog (S. cerevisiae) | 0.656 |
| SNX11 | ZFYVE1 | ENSP00000352175 | ENSP00000450742 | sorting nexin 11; May be involved in several stages of intracellular trafficking (By similarity) | zinc finger, FYVE domain containing 1 | 0.655 |
| SNX11 | ZFYVE19 | ENSP00000352175 | ENSP00000347498 | sorting nexin 11; May be involved in several stages of intracellular trafficking (By similarity) | zinc finger, FYVE domain containing 19 | 0.655 |
| SNX32 | SNX11 | ENSP00000310620 | ENSP00000352175 | sorting nexin 32; May be involved in several stages of intracellular trafficking (By similarity) | sorting nexin 11; May be involved in several stages of intracellular trafficking (By similarity) | 0.658 |
| SNX32 | VPS29 | ENSP00000310620 | ENSP00000380795 | sorting nexin 32; May be involved in several stages of intracellular trafficking (By similarity) | vacuolar protein sorting 29 homolog (S. cerevisiae); Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro) | 0.656 |
| SNX32 | VPS35 | ENSP00000310620 | ENSP00000299138 | sorting nexin 32; May be involved in several stages of intracellular trafficking (By similarity) | vacuolar protein sorting 35 homolog (S. cerevisiae) | 0.572 |
| SNX5 | HGS | ENSP00000366988 | ENSP00000331201 | sorting nexin 5; May be involved in several stages of intracellular trafficking. Plays a role in macropinocytosis. Plays a role in the internalization of EGFR after EGF stimulation | hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down- regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | 0.578 |
Share
