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STRINGSTRING
GMPS GMPS BABAM1 BABAM1 FAM175B FAM175B BRCA1 BRCA1 SLC25A13 SLC25A13 UBC UBC UIMC1 UIMC1 BRE BRE FAM175A FAM175A BRCC3 BRCC3 BARD1 BARD1
"BABAM1" - BRISC and BRCA1 A complex member 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
BABAM1BRISC and BRCA1 A complex member 1; Component of the BRCA1-A complex, a complex that specifically recognizes ’Lys-63’-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes ’Lys-63’-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprote [...] (329 aa)    
Predicted Functional Partners:
BRE
brain and reproductive organ-expressed (TNFRSF1A modulator) (415 aa)
        score_image score_image score_image   0.999
FAM175A
family with sequence similarity 175, member A; Component of the BRCA1-A complex, a complex that specifically recognizes ’Lys-63’-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes ’Lys-63’-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1 (409 aa)
        score_image score_image score_image   0.999
UIMC1
ubiquitin interaction motif containing 1 (719 aa)
        score_image score_image score_image   0.999
BRCC3
BRCA1/BRCA2-containing complex, subunit 3 (316 aa)
        score_image score_image score_image   0.999
FAM175B
family with sequence similarity 175, member B; Component of the BRISC complex, a multiprotein complex that specifically cleaves ’Lys-63’-linked ubiquitin. May act as a central scaffold protein that assembles the various components of the BRISC complex (415 aa)
        score_image score_image score_image   0.999
BRCA1
breast cancer 1, early onset; E3 ubiquitin-protein ligase that specifically mediates the formation of ’Lys-6’-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Reg [...] (1884 aa)
        score_image score_image score_image   0.995
UBC
ubiquitin C (685 aa)
        score_image   score_image   0.948
BARD1
BRCA1 associated RING domain 1; Probable E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of ’Lys-6’-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP I [...] (777 aa)
          score_image score_image   0.938
GMPS
guanine monphosphate synthetase; Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division (693 aa)
        score_image       0.891
SLC25A13
solute carrier family 25 (aspartate/glutamate carrier), member 13; Catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. May have a function in the urea cycle (676 aa)
        score_image       0.891
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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