Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
|
Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | LDLRAD4 | low density lipoprotein receptor class A domain containing 4 (306 aa) | ||||||||||||
Predicted Functional Partners:
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 | TSC22D1 | TSC22 domain family, member 1; Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter (1073 aa) |
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0.720 | ||||||||||
 | RBM41 | RNA binding motif protein 41; May bind RNA (Potential) (413 aa) |
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0.553 | ||||||||||
 | METTL15 | methyltransferase like 15; Probable S-adenosyl-L-methionine-dependent methyltransferase (By similarity) (407 aa) |
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0.505 | ||||||||||
 | TSC22D3 | TSC22 domain family, member 3; Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity) (200 aa) |
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0.503 | ||||||||||
 | AR | androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 (920 aa) |
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0.487 | ||||||||||
 | TSC22D4 | TSC22 domain family, member 4; Transcriptional repressor (395 aa) |
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0.472 | ||||||||||
 | TSC22D2 | TSC22 domain family, member 2 (780 aa) |
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0.471 | ||||||||||
 | UTP15 | UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae); Involved in nucleolar processing of pre-18S ribosomal RNA (By similarity) (518 aa) |
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0.439 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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