| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| HNRNPA1 | HNRNPC | ENSP00000341826 | ENSP00000319690 | heterogeneous nuclear ribonucleoprotein A1; Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.998 |
| HNRNPA1 | HNRNPD | ENSP00000341826 | ENSP00000313199 | heterogeneous nuclear ribonucleoprotein A1; Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | 0.994 |
| HNRNPA1 | HNRNPL | ENSP00000341826 | ENSP00000221419 | heterogeneous nuclear ribonucleoprotein A1; Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication | heterogeneous nuclear ribonucleoprotein L; This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Is associated with most nascent transcripts including those of the landmark giant loops of amphibian lampbrush chromosomes. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter | 0.998 |
| HNRNPA1 | PCBP2 | ENSP00000341826 | ENSP00000352438 | heterogeneous nuclear ribonucleoprotein A1; Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication | poly(rC) binding protein 2 | 0.968 |
| HNRNPA1 | PTBP1 | ENSP00000341826 | ENSP00000349428 | heterogeneous nuclear ribonucleoprotein A1; Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication | polypyrimidine tract binding protein 1; Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10 | 0.999 |
| HNRNPA1 | SF3B2 | ENSP00000341826 | ENSP00000318861 | heterogeneous nuclear ribonucleoprotein A1; Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication | splicing factor 3b, subunit 2, 145kDa; Subunit of the splicing factor SF3B required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron | 0.951 |
| HNRNPA1 | SRSF3 | ENSP00000341826 | ENSP00000362820 | heterogeneous nuclear ribonucleoprotein A1; Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication | serine/arginine-rich splicing factor 3; May be involved in RNA processing in relation with cellular proliferation and/or maturation | 0.973 |
| HNRNPA1 | SRSF4 | ENSP00000341826 | ENSP00000362900 | heterogeneous nuclear ribonucleoprotein A1; Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication | serine/arginine-rich splicing factor 4; Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10 | 0.977 |
| HNRNPA1 | UBC | ENSP00000341826 | ENSP00000344818 | heterogeneous nuclear ribonucleoprotein A1; Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication | ubiquitin C | 0.998 |
| HNRNPA1 | YBX1 | ENSP00000341826 | ENSP00000361626 | heterogeneous nuclear ribonucleoprotein A1; Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication | Y box binding protein 1; Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at ’Lys-6’ and ’Lys-7’. Binds to promoters that contain a Y-box (5’-CTGATTGGCCAA-3’), such as MD [...] | 0.969 |
| HNRNPC | HNRNPA1 | ENSP00000319690 | ENSP00000341826 | heterogeneous nuclear ribonucleoprotein C (C1/C2) | heterogeneous nuclear ribonucleoprotein A1; Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication | 0.998 |
| HNRNPC | HNRNPD | ENSP00000319690 | ENSP00000313199 | heterogeneous nuclear ribonucleoprotein C (C1/C2) | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | 0.995 |
| HNRNPC | HNRNPL | ENSP00000319690 | ENSP00000221419 | heterogeneous nuclear ribonucleoprotein C (C1/C2) | heterogeneous nuclear ribonucleoprotein L; This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Is associated with most nascent transcripts including those of the landmark giant loops of amphibian lampbrush chromosomes. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter | 0.956 |
| HNRNPC | PCBP2 | ENSP00000319690 | ENSP00000352438 | heterogeneous nuclear ribonucleoprotein C (C1/C2) | poly(rC) binding protein 2 | 0.968 |
| HNRNPC | PTBP1 | ENSP00000319690 | ENSP00000349428 | heterogeneous nuclear ribonucleoprotein C (C1/C2) | polypyrimidine tract binding protein 1; Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10 | 0.973 |
| HNRNPC | SF3B2 | ENSP00000319690 | ENSP00000318861 | heterogeneous nuclear ribonucleoprotein C (C1/C2) | splicing factor 3b, subunit 2, 145kDa; Subunit of the splicing factor SF3B required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron | 0.985 |
| HNRNPC | SRSF3 | ENSP00000319690 | ENSP00000362820 | heterogeneous nuclear ribonucleoprotein C (C1/C2) | serine/arginine-rich splicing factor 3; May be involved in RNA processing in relation with cellular proliferation and/or maturation | 0.966 |
| HNRNPC | SRSF4 | ENSP00000319690 | ENSP00000362900 | heterogeneous nuclear ribonucleoprotein C (C1/C2) | serine/arginine-rich splicing factor 4; Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10 | 0.941 |
| HNRNPC | UBC | ENSP00000319690 | ENSP00000344818 | heterogeneous nuclear ribonucleoprotein C (C1/C2) | ubiquitin C | 0.982 |
| HNRNPC | YBX1 | ENSP00000319690 | ENSP00000361626 | heterogeneous nuclear ribonucleoprotein C (C1/C2) | Y box binding protein 1; Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at ’Lys-6’ and ’Lys-7’. Binds to promoters that contain a Y-box (5’-CTGATTGGCCAA-3’), such as MD [...] | 0.966 |
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