node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AMBN | C1orf116 | ENSP00000313809 | ENSP00000352447 | ameloblastin (enamel matrix protein); Involved in the mineralization and structural organization of enamel | chromosome 1 open reading frame 116; Putative androgen-specific receptor | 0.681 |
C1orf116 | AMBN | ENSP00000352447 | ENSP00000313809 | chromosome 1 open reading frame 116; Putative androgen-specific receptor | ameloblastin (enamel matrix protein); Involved in the mineralization and structural organization of enamel | 0.681 |
C1orf116 | HOMER1 | ENSP00000352447 | ENSP00000334382 | chromosome 1 open reading frame 116; Putative androgen-specific receptor | homer homolog 1 (Drosophila); Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic m [...] | 0.945 |
C1orf116 | KIAA1383 | ENSP00000352447 | ENSP00000403208 | chromosome 1 open reading frame 116; Putative androgen-specific receptor | KIAA1383; Microtubule-associated protein (MAP) that plays a role in the regulation of cell division; promotes microtubule stability and participates in the organization of the spindle midzone and normal progress of cytokinesis | 0.414 |
C1orf116 | LSM4 | ENSP00000352447 | ENSP00000469468 | chromosome 1 open reading frame 116; Putative androgen-specific receptor | LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae); Binds specifically to the 3’-terminal U-tract of U6 snRNA | 0.500 |
C1orf116 | MTX1 | ENSP00000352447 | ENSP00000357360 | chromosome 1 open reading frame 116; Putative androgen-specific receptor | metaxin 1; Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity) | 0.608 |
C1orf116 | MTX3 | ENSP00000352447 | ENSP00000423600 | chromosome 1 open reading frame 116; Putative androgen-specific receptor | metaxin 3; Could function in transport of proteins into the mitochondrion (By similarity) | 0.637 |
C1orf116 | OS9 | ENSP00000352447 | ENSP00000318165 | chromosome 1 open reading frame 116; Putative androgen-specific receptor | osteosarcoma amplified 9, endoplasmic reticulum lectin | 0.587 |
C1orf116 | PPFIA3 | ENSP00000352447 | ENSP00000335614 | chromosome 1 open reading frame 116; Putative androgen-specific receptor | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3; May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates | 0.570 |
C1orf116 | SETD8 | ENSP00000352447 | ENSP00000332995 | chromosome 1 open reading frame 116; Putative androgen-specific receptor | SET domain containing (lysine methyltransferase) 8; Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates ’Lys-20’ of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome conden [...] | 0.468 |
C1orf116 | SUPV3L1 | ENSP00000352447 | ENSP00000352678 | chromosome 1 open reading frame 116; Putative androgen-specific receptor | suppressor of var1, 3-like 1 (S. cerevisiae); Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3’ overhang double-stranded RNA with a 3’-to-5’ directionality in an ATP-dependent manner. ATPase and ATP- dependent multisubstrate helicase, able to unwind double stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5’-to-3’ direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of no [...] | 0.628 |
HOMER1 | C1orf116 | ENSP00000334382 | ENSP00000352447 | homer homolog 1 (Drosophila); Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic m [...] | chromosome 1 open reading frame 116; Putative androgen-specific receptor | 0.945 |
KIAA1383 | C1orf116 | ENSP00000403208 | ENSP00000352447 | KIAA1383; Microtubule-associated protein (MAP) that plays a role in the regulation of cell division; promotes microtubule stability and participates in the organization of the spindle midzone and normal progress of cytokinesis | chromosome 1 open reading frame 116; Putative androgen-specific receptor | 0.414 |
LSM4 | C1orf116 | ENSP00000469468 | ENSP00000352447 | LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae); Binds specifically to the 3’-terminal U-tract of U6 snRNA | chromosome 1 open reading frame 116; Putative androgen-specific receptor | 0.500 |
MTX1 | C1orf116 | ENSP00000357360 | ENSP00000352447 | metaxin 1; Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity) | chromosome 1 open reading frame 116; Putative androgen-specific receptor | 0.608 |
MTX3 | C1orf116 | ENSP00000423600 | ENSP00000352447 | metaxin 3; Could function in transport of proteins into the mitochondrion (By similarity) | chromosome 1 open reading frame 116; Putative androgen-specific receptor | 0.637 |
OS9 | C1orf116 | ENSP00000318165 | ENSP00000352447 | osteosarcoma amplified 9, endoplasmic reticulum lectin | chromosome 1 open reading frame 116; Putative androgen-specific receptor | 0.587 |
PPFIA3 | C1orf116 | ENSP00000335614 | ENSP00000352447 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3; May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates | chromosome 1 open reading frame 116; Putative androgen-specific receptor | 0.570 |
SETD8 | C1orf116 | ENSP00000332995 | ENSP00000352447 | SET domain containing (lysine methyltransferase) 8; Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates ’Lys-20’ of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome conden [...] | chromosome 1 open reading frame 116; Putative androgen-specific receptor | 0.468 |
SUPV3L1 | C1orf116 | ENSP00000352678 | ENSP00000352447 | suppressor of var1, 3-like 1 (S. cerevisiae); Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3’ overhang double-stranded RNA with a 3’-to-5’ directionality in an ATP-dependent manner. ATPase and ATP- dependent multisubstrate helicase, able to unwind double stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5’-to-3’ direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of no [...] | chromosome 1 open reading frame 116; Putative androgen-specific receptor | 0.628 |