Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | TECPR2 | tectonin beta-propeller repeat containing 2 (1411 aa) | ||||||||||||
Predicted Functional Partners:
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 | WDR64 | WD repeat domain 64 (1081 aa) |
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0.471 | ||||||||||
 | KBTBD7 | kelch repeat and BTB (POZ) domain containing 7 (684 aa) |
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0.454 | ||||||||||
 | ATG2B | autophagy related 2B; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion (2078 aa) |
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0.451 | ||||||||||
 | ATG2A | autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion (1938 aa) |
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0.445 | ||||||||||
 | ZNF793 | zinc finger protein 793; May be involved in transcriptional regulation (406 aa) |
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0.441 | ||||||||||
 | RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic); Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (988 aa) |
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0.441 | ||||||||||
 | IGSF8 | immunoglobulin superfamily, member 8; May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility- suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin- dependent morphology and motility functions. May participate in th [...] (613 aa) |
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0.438 | ||||||||||
 | ZNF330 | zinc finger protein 330 (320 aa) |
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0.435 | ||||||||||
 | TRAPPC5 | trafficking protein particle complex 5; May play a role in vesicular transport from endoplasmic reticulum to Golgi (188 aa) |
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0.434 | ||||||||||
 | ANKFY1 | ankyrin repeat and FYVE domain containing 1 (1170 aa) |
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0.424 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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