| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMPD1 | MPZL1 | ENSP00000430075 | ENSP00000352513 | adenosine monophosphate deaminase 1; AMP deaminase plays a critical role in energy metabolism | myelin protein zero-like 1; Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine- protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility | 0.647 |
| GRAP2 | LCP2 | ENSP00000339186 | ENSP00000046794 | GRB2-related adaptor protein 2; Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc | lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa); Involved in T-cell antigen receptor mediated signaling | 0.999 |
| GRAP2 | MPZL1 | ENSP00000339186 | ENSP00000352513 | GRB2-related adaptor protein 2; Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc | myelin protein zero-like 1; Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine- protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility | 0.661 |
| GRAP2 | PTPN11 | ENSP00000339186 | ENSP00000340944 | GRB2-related adaptor protein 2; Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc | protein tyrosine phosphatase, non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity | 0.438 |
| GRAP2 | SIRPA | ENSP00000339186 | ENSP00000348307 | GRB2-related adaptor protein 2; Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc | signal-regulatory protein alpha | 0.538 |
| GRAP2 | SRC | ENSP00000339186 | ENSP00000350941 | GRB2-related adaptor protein 2; Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein- coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to f [...] | 0.469 |
| GRAP2 | UBC | ENSP00000339186 | ENSP00000344818 | GRB2-related adaptor protein 2; Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc | ubiquitin C | 0.527 |
| LCP2 | GRAP2 | ENSP00000046794 | ENSP00000339186 | lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa); Involved in T-cell antigen receptor mediated signaling | GRB2-related adaptor protein 2; Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc | 0.999 |
| LCP2 | MPZL1 | ENSP00000046794 | ENSP00000352513 | lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa); Involved in T-cell antigen receptor mediated signaling | myelin protein zero-like 1; Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine- protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility | 0.497 |
| LCP2 | NR0B2 | ENSP00000046794 | ENSP00000254227 | lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa); Involved in T-cell antigen receptor mediated signaling | nuclear receptor subfamily 0, group B, member 2; Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box- containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1 | 0.871 |
| LCP2 | PTPN11 | ENSP00000046794 | ENSP00000340944 | lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa); Involved in T-cell antigen receptor mediated signaling | protein tyrosine phosphatase, non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity | 0.964 |
| LCP2 | PTPN6 | ENSP00000046794 | ENSP00000391592 | lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa); Involved in T-cell antigen receptor mediated signaling | protein tyrosine phosphatase, non-receptor type 6; Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis | 0.920 |
| LCP2 | SRC | ENSP00000046794 | ENSP00000350941 | lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa); Involved in T-cell antigen receptor mediated signaling | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein- coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to f [...] | 0.880 |
| MPZ | MPZL1 | ENSP00000431538 | ENSP00000352513 | myelin protein zero; Creation of an extracellular membrane face which guides the wrapping process and ultimately compacts adjacent lamellae | myelin protein zero-like 1; Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine- protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility | 0.800 |
| MPZL1 | AMPD1 | ENSP00000352513 | ENSP00000430075 | myelin protein zero-like 1; Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine- protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility | adenosine monophosphate deaminase 1; AMP deaminase plays a critical role in energy metabolism | 0.647 |
| MPZL1 | GRAP2 | ENSP00000352513 | ENSP00000339186 | myelin protein zero-like 1; Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine- protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility | GRB2-related adaptor protein 2; Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc | 0.661 |
| MPZL1 | LCP2 | ENSP00000352513 | ENSP00000046794 | myelin protein zero-like 1; Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine- protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility | lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa); Involved in T-cell antigen receptor mediated signaling | 0.497 |
| MPZL1 | MPZ | ENSP00000352513 | ENSP00000431538 | myelin protein zero-like 1; Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine- protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility | myelin protein zero; Creation of an extracellular membrane face which guides the wrapping process and ultimately compacts adjacent lamellae | 0.800 |
| MPZL1 | NR0B2 | ENSP00000352513 | ENSP00000254227 | myelin protein zero-like 1; Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine- protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility | nuclear receptor subfamily 0, group B, member 2; Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box- containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1 | 0.804 |
| MPZL1 | PTPN11 | ENSP00000352513 | ENSP00000340944 | myelin protein zero-like 1; Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine- protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility | protein tyrosine phosphatase, non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity | 0.962 |
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