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HOXD13 HOXD13 DLX6 DLX6 PHOX2B PHOX2B NKX3-2 NKX3-2 HAND2 HAND2 HAND1 HAND1 MEF2A MEF2A MEF2C MEF2C ADSS ADSS NKX2-5 NKX2-5 GATA4 GATA4
"HAND2" - heart and neural crest derivatives expressed 2 in Homo sapiens
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HAND2heart and neural crest derivatives expressed 2; Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and nec [...] (217 aa)    
Predicted Functional Partners:
GATA4
GATA binding protein 4; Transcriptional activator. Binds to the consensus sequence 5’-AGATAG-3’. Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement (442 aa)
        score_image   score_image   0.995
MEF2C
myocyte enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platel [...] (483 aa)
          score_image score_image   0.994
NKX2-5
NK2 homeobox 5; Implicated in commitment to and/or differentiation of the myocardial lineage. Acts as a transcriptional activator of ANF in cooperation with GATA4 (By similarity) (324 aa)
        score_image score_image score_image   0.991
HAND1
heart and neural crest derivatives expressed 1; Transcription factor that plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis. In the adult, could be required for ongoing expression of cardiac-specific genes. Binds the DNA sequence 5’- NRTCTG-3’ (non-canonical E-box) (By similarity) (215 aa)
        score_image score_image score_image score_image 0.964
NKX3-2
NK3 homeobox 2; Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus (By similarity) (333 aa)
            score_image   0.963
MEF2A
myocyte enhancer factor 2A (499 aa)
            score_image   0.959
DLX6
distal-less homeobox 6 (293 aa)
            score_image   0.935
HOXD13
homeobox D13; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (343 aa)
        score_image   score_image   0.933
ADSS
adenylosuccinate synthase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP (By similarity) (456 aa)
          score_image score_image   0.917
PHOX2B
paired-like homeobox 2b; Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus. Transcription factor which could determine a neurotransmitter phenotype in vertebrates. Enhances second-messenger-mediated activation of the dopamine beta-hydrolase and c-fos promoters, and of several enhancers including cAMP-response element and serum- response element (314 aa)
            score_image   0.914
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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