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SLMAP SLMAP STRIP1 STRIP1 STRN4 STRN4 STRN STRN CTTNBP2NL CTTNBP2NL ZRANB1 ZRANB1 HECTD1 HECTD1 STRN3 STRN3 UBC UBC PGAM5 PGAM5 KEAP1 KEAP1
"ZRANB1" - zinc finger, RAN-binding domain containing 1 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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second shell of interactors
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Predicted Interactions
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protein homology
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ZRANB1zinc finger, RAN-binding domain containing 1; Specifically hydrolyzes ’Lys-29’-linked and ’Lys-33’- linked diubiquitin. Also cleaves ’Lys-63’-linked chains, but with 40-fold less efficiency compared to ’Lys-29’-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling (708 aa)    
Predicted Functional Partners:
UBC
ubiquitin C (685 aa)
        score_image   score_image   0.994
HECTD1
HECT domain containing E3 ubiquitin protein ligase 1; Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. May be required for development of the head mesenchyme and neural tube closure (By similarity) (2610 aa)
        score_image   score_image   0.927
STRIP1
striatin interacting protein 1; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape (837 aa)
        score_image   score_image   0.896
PGAM5
phosphoglycerate mutase family member 5; Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2- dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore (289 aa)
        score_image       0.891
KEAP1
kelch-like ECH-associated protein 1; Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (624 aa)
        score_image       0.891
STRN3
striatin, calmodulin binding protein 3; Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein (797 aa)
        score_image   score_image   0.886
STRN
striatin, calmodulin binding protein; Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic Ca(2+) signaling (780 aa)
        score_image   score_image   0.886
SLMAP
sarcolemma associated protein (811 aa)
        score_image   score_image   0.884
STRN4
striatin, calmodulin binding protein 4; Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein (760 aa)
        score_image       0.884
CTTNBP2NL
CTTNBP2 N-terminal like (639 aa)
        score_image       0.884
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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