node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CTTNBP2NL | SLMAP | ENSP00000271277 | ENSP00000295951 | CTTNBP2 N-terminal like | sarcolemma associated protein | 0.659 |
CTTNBP2NL | STRIP1 | ENSP00000271277 | ENSP00000358810 | CTTNBP2 N-terminal like | striatin interacting protein 1; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape | 0.999 |
CTTNBP2NL | STRN | ENSP00000271277 | ENSP00000263918 | CTTNBP2 N-terminal like | striatin, calmodulin binding protein; Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic Ca(2+) signaling | 0.999 |
CTTNBP2NL | STRN3 | ENSP00000271277 | ENSP00000350071 | CTTNBP2 N-terminal like | striatin, calmodulin binding protein 3; Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein | 0.999 |
CTTNBP2NL | STRN4 | ENSP00000271277 | ENSP00000375777 | CTTNBP2 N-terminal like | striatin, calmodulin binding protein 4; Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein | 0.999 |
CTTNBP2NL | UBC | ENSP00000271277 | ENSP00000344818 | CTTNBP2 N-terminal like | ubiquitin C | 0.483 |
CTTNBP2NL | ZRANB1 | ENSP00000271277 | ENSP00000352676 | CTTNBP2 N-terminal like | zinc finger, RAN-binding domain containing 1; Specifically hydrolyzes ’Lys-29’-linked and ’Lys-33’- linked diubiquitin. Also cleaves ’Lys-63’-linked chains, but with 40-fold less efficiency compared to ’Lys-29’-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling | 0.884 |
HECTD1 | STRN3 | ENSP00000382269 | ENSP00000350071 | HECT domain containing E3 ubiquitin protein ligase 1; Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. May be required for development of the head mesenchyme and neural tube closure (By similarity) | striatin, calmodulin binding protein 3; Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein | 0.526 |
HECTD1 | UBC | ENSP00000382269 | ENSP00000344818 | HECT domain containing E3 ubiquitin protein ligase 1; Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. May be required for development of the head mesenchyme and neural tube closure (By similarity) | ubiquitin C | 0.998 |
HECTD1 | ZRANB1 | ENSP00000382269 | ENSP00000352676 | HECT domain containing E3 ubiquitin protein ligase 1; Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. May be required for development of the head mesenchyme and neural tube closure (By similarity) | zinc finger, RAN-binding domain containing 1; Specifically hydrolyzes ’Lys-29’-linked and ’Lys-33’- linked diubiquitin. Also cleaves ’Lys-63’-linked chains, but with 40-fold less efficiency compared to ’Lys-29’-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling | 0.927 |
KEAP1 | PGAM5 | ENSP00000171111 | ENSP00000438465 | kelch-like ECH-associated protein 1; Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome | phosphoglycerate mutase family member 5; Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2- dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore | 0.999 |
KEAP1 | UBC | ENSP00000171111 | ENSP00000344818 | kelch-like ECH-associated protein 1; Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome | ubiquitin C | 0.999 |
KEAP1 | ZRANB1 | ENSP00000171111 | ENSP00000352676 | kelch-like ECH-associated protein 1; Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome | zinc finger, RAN-binding domain containing 1; Specifically hydrolyzes ’Lys-29’-linked and ’Lys-33’- linked diubiquitin. Also cleaves ’Lys-63’-linked chains, but with 40-fold less efficiency compared to ’Lys-29’-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling | 0.891 |
PGAM5 | KEAP1 | ENSP00000438465 | ENSP00000171111 | phosphoglycerate mutase family member 5; Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2- dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore | kelch-like ECH-associated protein 1; Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome | 0.999 |
PGAM5 | STRN | ENSP00000438465 | ENSP00000263918 | phosphoglycerate mutase family member 5; Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2- dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore | striatin, calmodulin binding protein; Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic Ca(2+) signaling | 0.615 |
PGAM5 | STRN3 | ENSP00000438465 | ENSP00000350071 | phosphoglycerate mutase family member 5; Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2- dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore | striatin, calmodulin binding protein 3; Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein | 0.615 |
PGAM5 | UBC | ENSP00000438465 | ENSP00000344818 | phosphoglycerate mutase family member 5; Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2- dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore | ubiquitin C | 0.998 |
PGAM5 | ZRANB1 | ENSP00000438465 | ENSP00000352676 | phosphoglycerate mutase family member 5; Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2- dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore | zinc finger, RAN-binding domain containing 1; Specifically hydrolyzes ’Lys-29’-linked and ’Lys-33’- linked diubiquitin. Also cleaves ’Lys-63’-linked chains, but with 40-fold less efficiency compared to ’Lys-29’-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling | 0.891 |
SLMAP | CTTNBP2NL | ENSP00000295951 | ENSP00000271277 | sarcolemma associated protein | CTTNBP2 N-terminal like | 0.659 |
SLMAP | STRIP1 | ENSP00000295951 | ENSP00000358810 | sarcolemma associated protein | striatin interacting protein 1; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape | 0.999 |