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SCD SCD RPL3L RPL3L UBC UBC TIAL1 TIAL1 PRKCA PRKCA G3BP2 G3BP2 USP10 USP10 LGALS3 LGALS3 DHX8 DHX8 STYXL1 STYXL1 SH2D3C SH2D3C
"G3BP2" - GTPase activating protein (SH3 domain) binding protein 2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
G3BP2GTPase activating protein (SH3 domain) binding protein 2; Probable scaffold protein that may be involved in mRNA transport (Potential) (482 aa)    
Predicted Functional Partners:
USP10
ubiquitin specific peptidase 10; Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability- in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels- mediates deubiquitination of BECN1, a key [...] (798 aa)
      score_image score_image   score_image   0.996
UBC
ubiquitin C (685 aa)
        score_image   score_image   0.948
TIAL1
TIA1 cytotoxic granule-associated RNA binding protein-like 1; RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis (392 aa)
      score_image     score_image   0.914
SH2D3C
SH2 domain containing 3C; Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is required to induce membrane ruffling and promote EGF-dependent cell migration (By similarity) (860 aa)
            score_image   0.854
DHX8
DEAH (Asp-Glu-Ala-His) box polypeptide 8; Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome (1220 aa)
        score_image   score_image   0.853
PRKCA
protein kinase C, alpha; Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycl [...] (672 aa)
        score_image   score_image   0.813
RPL3L
ribosomal protein L3-like (407 aa)
        score_image       0.812
SCD
stearoyl-CoA desaturase (delta-9-desaturase) (359 aa)
            score_image   0.802
STYXL1
serine/threonine/tyrosine interacting-like 1 (313 aa)
        score_image   score_image   0.801
LGALS3
lectin, galactoside-binding, soluble, 3; Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus- acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells (250 aa)
            score_image   0.791
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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