Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | NPSR1 | neuropeptide S receptor 1 (377 aa) | ||||||||||||
Predicted Functional Partners:
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 | RPL15 | ribosomal protein L15 (204 aa) |
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0.993 | ||||||||
 | RPL35 | ribosomal protein L35 (123 aa) |
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0.993 | ||||||||
 | RPL13A | ribosomal protein L13a; Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3’-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses [...] (203 aa) |
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0.993 | ||||||||
 | RPL17 | ribosomal protein L17 (184 aa) |
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0.991 | |||||||||
 | ENSG00000215472 | 60S ribosomal protein L17 isoform a (184 aa) |
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0.991 | |||||||||
 | RPL4 | ribosomal protein L4 (427 aa) |
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0.990 | ||||||||
 | RPL9 | ribosomal protein L9 (192 aa) |
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0.988 | ||||||||
 | RPL21 | ribosomal protein L21 (160 aa) |
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0.988 | ||||||||
 | RPL24 | ribosomal protein L24 (157 aa) |
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0.988 | ||||||||
 | RPL18 | ribosomal protein L18 (188 aa) |
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0.987 | ||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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