node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ECD | UBC | ENSP00000401566 | ENSP00000344818 | ecdysoneless homolog (Drosophila); Novel regulator of p53 stability and function. May also be a transcriptional activator required for the expression of glycolytic genes | ubiquitin C | 0.728 |
ECD | ZNF808 | ENSP00000401566 | ENSP00000352846 | ecdysoneless homolog (Drosophila); Novel regulator of p53 stability and function. May also be a transcriptional activator required for the expression of glycolytic genes | zinc finger protein 808; May be involved in transcriptional regulation | 0.577 |
FBXL19 | ZNF808 | ENSP00000369666 | ENSP00000352846 | F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | zinc finger protein 808; May be involved in transcriptional regulation | 0.501 |
GPRC5C | UBC | ENSP00000376403 | ENSP00000344818 | G protein-coupled receptor, family C, group 5, member C; This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways (By similarity) | ubiquitin C | 0.620 |
GPRC5C | ZNF808 | ENSP00000376403 | ENSP00000352846 | G protein-coupled receptor, family C, group 5, member C; This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways (By similarity) | zinc finger protein 808; May be involved in transcriptional regulation | 0.482 |
KDM2A | UBC | ENSP00000432786 | ENSP00000344818 | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | ubiquitin C | 0.740 |
KDM2A | ZNF808 | ENSP00000432786 | ENSP00000352846 | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | zinc finger protein 808; May be involved in transcriptional regulation | 0.501 |
KDM2B | UBC | ENSP00000366271 | ENSP00000344818 | lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...] | ubiquitin C | 0.514 |
KDM2B | ZNF808 | ENSP00000366271 | ENSP00000352846 | lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...] | zinc finger protein 808; May be involved in transcriptional regulation | 0.501 |
LRRC56 | ZNF808 | ENSP00000270115 | ENSP00000352846 | leucine rich repeat containing 56 | zinc finger protein 808; May be involved in transcriptional regulation | 0.524 |
OR4D1 | ZNF808 | ENSP00000365451 | ENSP00000352846 | olfactory receptor, family 4, subfamily D, member 1; Odorant receptor (Potential) | zinc finger protein 808; May be involved in transcriptional regulation | 0.581 |
PTPN23 | UBC | ENSP00000265562 | ENSP00000344818 | protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis | ubiquitin C | 0.958 |
PTPN23 | ZNF808 | ENSP00000265562 | ENSP00000352846 | protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis | zinc finger protein 808; May be involved in transcriptional regulation | 0.476 |
UBC | ECD | ENSP00000344818 | ENSP00000401566 | ubiquitin C | ecdysoneless homolog (Drosophila); Novel regulator of p53 stability and function. May also be a transcriptional activator required for the expression of glycolytic genes | 0.728 |
UBC | GPRC5C | ENSP00000344818 | ENSP00000376403 | ubiquitin C | G protein-coupled receptor, family C, group 5, member C; This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways (By similarity) | 0.620 |
UBC | KDM2A | ENSP00000344818 | ENSP00000432786 | ubiquitin C | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | 0.740 |
UBC | KDM2B | ENSP00000344818 | ENSP00000366271 | ubiquitin C | lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...] | 0.514 |
UBC | PTPN23 | ENSP00000344818 | ENSP00000265562 | ubiquitin C | protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis | 0.958 |
UBC | XRN1 | ENSP00000344818 | ENSP00000264951 | ubiquitin C | 5’-3’ exoribonuclease 1; Major 5’-3’ exoribonuclease involved in mRNA decay. Required for the 5’-3’-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS) | 0.885 |
UBC | ZNF808 | ENSP00000344818 | ENSP00000352846 | ubiquitin C | zinc finger protein 808; May be involved in transcriptional regulation | 0.685 |