node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CHGA | MEN1 | ENSP00000216492 | ENSP00000337088 | chromogranin A (parathyroid secretory protein 1); Pancreastatin strongly inhibits glucose induced insulin release from the pancreas | multiple endocrine neoplasia I | 0.624 |
CHGA | SPINK5 | ENSP00000216492 | ENSP00000352936 | chromogranin A (parathyroid secretory protein 1); Pancreastatin strongly inhibits glucose induced insulin release from the pancreas | serine peptidase inhibitor, Kazal type 5 | 0.757 |
CHGA | SST | ENSP00000216492 | ENSP00000287641 | chromogranin A (parathyroid secretory protein 1); Pancreastatin strongly inhibits glucose induced insulin release from the pancreas | somatostatin; Somatostatin inhibits the release of somatotropin | 0.824 |
KLK5 | LAP3 | ENSP00000337733 | ENSP00000226299 | kallikrein-related peptidase 5; May be involved in desquamation | leucine aminopeptidase 3; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides | 0.568 |
KLK5 | SPINK5 | ENSP00000337733 | ENSP00000352936 | kallikrein-related peptidase 5; May be involved in desquamation | serine peptidase inhibitor, Kazal type 5 | 0.658 |
KLK7 | LAP3 | ENSP00000375683 | ENSP00000226299 | kallikrein-related peptidase 7; May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. SCCE cleaves insulin B chain at ’6-Leu-|-Cys-7’, ’16-Tyr-|-Leu-17’, ’25-Phe-|-Tyr-26’ and ’26-Tyr-|-Thr-27’. Could play a role in the activation of precursors to inflammatory cytokines | leucine aminopeptidase 3; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides | 0.504 |
KLK7 | SPINK5 | ENSP00000375683 | ENSP00000352936 | kallikrein-related peptidase 7; May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. SCCE cleaves insulin B chain at ’6-Leu-|-Cys-7’, ’16-Tyr-|-Leu-17’, ’25-Phe-|-Tyr-26’ and ’26-Tyr-|-Thr-27’. Could play a role in the activation of precursors to inflammatory cytokines | serine peptidase inhibitor, Kazal type 5 | 0.702 |
LAP3 | KLK5 | ENSP00000226299 | ENSP00000337733 | leucine aminopeptidase 3; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides | kallikrein-related peptidase 5; May be involved in desquamation | 0.568 |
LAP3 | KLK7 | ENSP00000226299 | ENSP00000375683 | leucine aminopeptidase 3; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides | kallikrein-related peptidase 7; May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. SCCE cleaves insulin B chain at ’6-Leu-|-Cys-7’, ’16-Tyr-|-Leu-17’, ’25-Phe-|-Tyr-26’ and ’26-Tyr-|-Thr-27’. Could play a role in the activation of precursors to inflammatory cytokines | 0.504 |
LAP3 | SPINK5 | ENSP00000226299 | ENSP00000352936 | leucine aminopeptidase 3; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides | serine peptidase inhibitor, Kazal type 5 | 0.670 |
LAP3 | SST | ENSP00000226299 | ENSP00000287641 | leucine aminopeptidase 3; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides | somatostatin; Somatostatin inhibits the release of somatotropin | 0.453 |
LAP3 | ST14 | ENSP00000226299 | ENSP00000278742 | leucine aminopeptidase 3; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides | suppression of tumorigenicity 14 (colon carcinoma); Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site | 0.750 |
LPA | SPINK5 | ENSP00000321334 | ENSP00000352936 | lipoprotein, Lp(a); Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330 | serine peptidase inhibitor, Kazal type 5 | 0.632 |
MEN1 | CHGA | ENSP00000337088 | ENSP00000216492 | multiple endocrine neoplasia I | chromogranin A (parathyroid secretory protein 1); Pancreastatin strongly inhibits glucose induced insulin release from the pancreas | 0.624 |
MEN1 | SPINK5 | ENSP00000337088 | ENSP00000352936 | multiple endocrine neoplasia I | serine peptidase inhibitor, Kazal type 5 | 0.648 |
MEN1 | SST | ENSP00000337088 | ENSP00000287641 | multiple endocrine neoplasia I | somatostatin; Somatostatin inhibits the release of somatotropin | 0.923 |
PPP2CA | SPINK5 | ENSP00000418447 | ENSP00000352936 | protein phosphatase 2, catalytic subunit, alpha isozyme; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at ’Ser-259’ | serine peptidase inhibitor, Kazal type 5 | 0.822 |
SFTPD | SPINK5 | ENSP00000361366 | ENSP00000352936 | surfactant protein D; Contributes to the lung’s defense against inhaled microorganisms. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties | serine peptidase inhibitor, Kazal type 5 | 0.834 |
SPINK5 | CHGA | ENSP00000352936 | ENSP00000216492 | serine peptidase inhibitor, Kazal type 5 | chromogranin A (parathyroid secretory protein 1); Pancreastatin strongly inhibits glucose induced insulin release from the pancreas | 0.757 |
SPINK5 | KLK5 | ENSP00000352936 | ENSP00000337733 | serine peptidase inhibitor, Kazal type 5 | kallikrein-related peptidase 5; May be involved in desquamation | 0.658 |