node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CLN3 | CLN5 | ENSP00000353073 | ENSP00000366673 | ceroid-lipofuscinosis, neuronal 3 | ceroid-lipofuscinosis, neuronal 5 | 0.909 |
CLN3 | CLN6 | ENSP00000353073 | ENSP00000249806 | ceroid-lipofuscinosis, neuronal 3 | ceroid-lipofuscinosis, neuronal 6, late infantile, variant | 0.888 |
CLN3 | CLN8 | ENSP00000353073 | ENSP00000328182 | ceroid-lipofuscinosis, neuronal 3 | ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation); Could play a role in cell proliferation during neuronal differentiation and in protection against cell death | 0.900 |
CLN3 | KCNIP3 | ENSP00000353073 | ENSP00000295225 | ceroid-lipofuscinosis, neuronal 3 | Kv channel interacting protein 3, calsenilin; Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity) | 0.847 |
CLN3 | PPT1 | ENSP00000353073 | ENSP00000394863 | ceroid-lipofuscinosis, neuronal 3 | palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons | 0.900 |
CLN3 | STX5 | ENSP00000353073 | ENSP00000294179 | ceroid-lipofuscinosis, neuronal 3 | syntaxin 5; Mediates endoplasmic reticulum to Golgi transport (By similarity) | 0.835 |
CLN3 | TPP1 | ENSP00000353073 | ENSP00000299427 | ceroid-lipofuscinosis, neuronal 3 | tripeptidyl peptidase I; Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity) | 0.925 |
CLN3 | UBC | ENSP00000353073 | ENSP00000344818 | ceroid-lipofuscinosis, neuronal 3 | ubiquitin C | 0.924 |
CLN3 | VTI1A | ENSP00000353073 | ENSP00000376792 | ceroid-lipofuscinosis, neuronal 3 | vesicle transport through interaction with t-SNAREs homolog 1A (yeast); V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non- conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with [...] | 0.838 |
CLN3 | YKT6 | ENSP00000353073 | ENSP00000223369 | ceroid-lipofuscinosis, neuronal 3 | YKT6 v-SNARE homolog (S. cerevisiae); Vesicular soluble NSF attachment protein receptor (v- SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity | 0.830 |
CLN5 | CLN3 | ENSP00000366673 | ENSP00000353073 | ceroid-lipofuscinosis, neuronal 5 | ceroid-lipofuscinosis, neuronal 3 | 0.909 |
CLN5 | CLN6 | ENSP00000366673 | ENSP00000249806 | ceroid-lipofuscinosis, neuronal 5 | ceroid-lipofuscinosis, neuronal 6, late infantile, variant | 0.898 |
CLN5 | CLN8 | ENSP00000366673 | ENSP00000328182 | ceroid-lipofuscinosis, neuronal 5 | ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation); Could play a role in cell proliferation during neuronal differentiation and in protection against cell death | 0.891 |
CLN5 | PPT1 | ENSP00000366673 | ENSP00000394863 | ceroid-lipofuscinosis, neuronal 5 | palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons | 0.779 |
CLN5 | TPP1 | ENSP00000366673 | ENSP00000299427 | ceroid-lipofuscinosis, neuronal 5 | tripeptidyl peptidase I; Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity) | 0.960 |
CLN5 | UBC | ENSP00000366673 | ENSP00000344818 | ceroid-lipofuscinosis, neuronal 5 | ubiquitin C | 0.483 |
CLN6 | CLN3 | ENSP00000249806 | ENSP00000353073 | ceroid-lipofuscinosis, neuronal 6, late infantile, variant | ceroid-lipofuscinosis, neuronal 3 | 0.888 |
CLN6 | CLN5 | ENSP00000249806 | ENSP00000366673 | ceroid-lipofuscinosis, neuronal 6, late infantile, variant | ceroid-lipofuscinosis, neuronal 5 | 0.898 |
CLN6 | CLN8 | ENSP00000249806 | ENSP00000328182 | ceroid-lipofuscinosis, neuronal 6, late infantile, variant | ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation); Could play a role in cell proliferation during neuronal differentiation and in protection against cell death | 0.901 |
CLN6 | PPT1 | ENSP00000249806 | ENSP00000394863 | ceroid-lipofuscinosis, neuronal 6, late infantile, variant | palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons | 0.820 |