| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AGRP | DMBX1 | ENSP00000290953 | ENSP00000353132 | agouti related protein homolog (mouse); Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner | diencephalon/mesencephalon homeobox 1; Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5’-TAATCCGATTA-3’) sequence. Required for brain development (By similarity) | 0.609 |
| ALDH5A1 | DMBX1 | ENSP00000314649 | ENSP00000353132 | aldehyde dehydrogenase 5 family, member A1; Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) | diencephalon/mesencephalon homeobox 1; Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5’-TAATCCGATTA-3’) sequence. Required for brain development (By similarity) | 0.485 |
| ALDH5A1 | GPRIN2 | ENSP00000314649 | ENSP00000363433 | aldehyde dehydrogenase 5 family, member A1; Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) | G protein regulated inducer of neurite outgrowth 2 | 0.686 |
| DMBX1 | AGRP | ENSP00000353132 | ENSP00000290953 | diencephalon/mesencephalon homeobox 1; Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5’-TAATCCGATTA-3’) sequence. Required for brain development (By similarity) | agouti related protein homolog (mouse); Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner | 0.609 |
| DMBX1 | ALDH5A1 | ENSP00000353132 | ENSP00000314649 | diencephalon/mesencephalon homeobox 1; Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5’-TAATCCGATTA-3’) sequence. Required for brain development (By similarity) | aldehyde dehydrogenase 5 family, member A1; Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) | 0.485 |
| DMBX1 | FOXC2 | ENSP00000353132 | ENSP00000326371 | diencephalon/mesencephalon homeobox 1; Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5’-TAATCCGATTA-3’) sequence. Required for brain development (By similarity) | forkhead box C2 (MFH-1, mesenchyme forkhead 1); Transcriptional activator. Might be involved in the formation of special mesenchymal tissues | 0.465 |
| DMBX1 | FOXD3 | ENSP00000353132 | ENSP00000360157 | diencephalon/mesencephalon homeobox 1; Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5’-TAATCCGATTA-3’) sequence. Required for brain development (By similarity) | forkhead box D3; Binds to the consensus sequence 5’-A[AT]T[AG]TTTGTTT-3’ and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis | 0.470 |
| DMBX1 | FOXG1 | ENSP00000353132 | ENSP00000339004 | diencephalon/mesencephalon homeobox 1; Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5’-TAATCCGATTA-3’) sequence. Required for brain development (By similarity) | forkhead box G1; Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon | 0.495 |
| DMBX1 | GPRIN2 | ENSP00000353132 | ENSP00000363433 | diencephalon/mesencephalon homeobox 1; Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5’-TAATCCGATTA-3’) sequence. Required for brain development (By similarity) | G protein regulated inducer of neurite outgrowth 2 | 0.578 |
| DMBX1 | LEUTX | ENSP00000353132 | ENSP00000380053 | diencephalon/mesencephalon homeobox 1; Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5’-TAATCCGATTA-3’) sequence. Required for brain development (By similarity) | leucine twenty homeobox | 0.502 |
| DMBX1 | OTX2 | ENSP00000353132 | ENSP00000343819 | diencephalon/mesencephalon homeobox 1; Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5’-TAATCCGATTA-3’) sequence. Required for brain development (By similarity) | orthodenticle homeobox 2; Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS)- 5’-TCTAATCCC-3’ | 0.671 |
| DMBX1 | SRF | ENSP00000353132 | ENSP00000265354 | diencephalon/mesencephalon homeobox 1; Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5’-TAATCCGATTA-3’) sequence. Required for brain development (By similarity) | serum response factor (c-fos serum response element-binding transcription factor); SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5’ of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation | 0.696 |
| DMBX1 | SYT15 | ENSP00000353132 | ENSP00000363441 | diencephalon/mesencephalon homeobox 1; Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5’-TAATCCGATTA-3’) sequence. Required for brain development (By similarity) | synaptotagmin XV; May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues (By similarity) | 0.470 |
| FOXC2 | DMBX1 | ENSP00000326371 | ENSP00000353132 | forkhead box C2 (MFH-1, mesenchyme forkhead 1); Transcriptional activator. Might be involved in the formation of special mesenchymal tissues | diencephalon/mesencephalon homeobox 1; Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5’-TAATCCGATTA-3’) sequence. Required for brain development (By similarity) | 0.465 |
| FOXC2 | SRF | ENSP00000326371 | ENSP00000265354 | forkhead box C2 (MFH-1, mesenchyme forkhead 1); Transcriptional activator. Might be involved in the formation of special mesenchymal tissues | serum response factor (c-fos serum response element-binding transcription factor); SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5’ of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation | 0.540 |
| FOXD3 | DMBX1 | ENSP00000360157 | ENSP00000353132 | forkhead box D3; Binds to the consensus sequence 5’-A[AT]T[AG]TTTGTTT-3’ and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis | diencephalon/mesencephalon homeobox 1; Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5’-TAATCCGATTA-3’) sequence. Required for brain development (By similarity) | 0.470 |
| FOXD3 | SRF | ENSP00000360157 | ENSP00000265354 | forkhead box D3; Binds to the consensus sequence 5’-A[AT]T[AG]TTTGTTT-3’ and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis | serum response factor (c-fos serum response element-binding transcription factor); SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5’ of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation | 0.522 |
| FOXG1 | DMBX1 | ENSP00000339004 | ENSP00000353132 | forkhead box G1; Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon | diencephalon/mesencephalon homeobox 1; Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5’-TAATCCGATTA-3’) sequence. Required for brain development (By similarity) | 0.495 |
| FOXG1 | OTX2 | ENSP00000339004 | ENSP00000343819 | forkhead box G1; Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon | orthodenticle homeobox 2; Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS)- 5’-TCTAATCCC-3’ | 0.666 |
| FOXG1 | SRF | ENSP00000339004 | ENSP00000265354 | forkhead box G1; Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon | serum response factor (c-fos serum response element-binding transcription factor); SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5’ of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation | 0.953 |
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