Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | ARL9 | ADP-ribosylation factor-like 9 (187 aa) | ||||||||||||
Predicted Functional Partners:
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 | RASL11A | RAS-like, family 11, member A; Regulator of rDNA transcription. Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I transcription (By similarity) (242 aa) |
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0.871 | |||||||||
 | RASL11B | RAS-like, family 11, member B (248 aa) |
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0.816 | |||||||||
 | ARL16 | ADP-ribosylation factor-like 16 (197 aa) |
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0.739 | ||||||||
 | SRP72 | signal recognition particle 72kDa; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. Binds the 7S RNA only in presence of SRP68. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function (671 aa) |
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0.720 | ||||||||||
 | TAPT1 | transmembrane anterior posterior transformation 1; May act as a downstream effector of HOXC8 possibly by transducing or transmitting extracellular information required for axial skeletal patterning during development (By similarity). In case of infection, may act as a fusion receptor for cytomegalovirus (HCMV) strain AD169 (567 aa) |
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0.715 | ||||||||||
 | SPATA5 | spermatogenesis associated 5; May be involved in morphological and functional mitochondrial transformations during spermatogenesis (By similarity) (893 aa) |
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0.699 | |||||||||
 | TMEM33 | transmembrane protein 33 (247 aa) |
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0.688 | |||||||||
 | RAB43 | RAB43, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport o [...] (212 aa) |
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0.688 | |||||||||
 | ANKRD50 | ankyrin repeat domain 50 (1429 aa) |
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0.686 | |||||||||
 | ADAD1 | adenosine deaminase domain containing 1 (testis-specific); Plays a role in spermatogenesis. Binds to RNA but not to DNA (By similarity) (576 aa) |
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0.684 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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