node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COPB1 | ERGIC2 | ENSP00000249923 | ENSP00000353270 | coatomer protein complex, subunit beta 1; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; th [...] | ERGIC and golgi 2; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) | 0.718 |
COPB1 | ERGIC3 | ENSP00000249923 | ENSP00000349970 | coatomer protein complex, subunit beta 1; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; th [...] | ERGIC and golgi 3; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) | 0.439 |
COPB1 | UBC | ENSP00000249923 | ENSP00000344818 | coatomer protein complex, subunit beta 1; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; th [...] | ubiquitin C | 0.967 |
ERGIC2 | COPB1 | ENSP00000353270 | ENSP00000249923 | ERGIC and golgi 2; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) | coatomer protein complex, subunit beta 1; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; th [...] | 0.718 |
ERGIC2 | ERGIC3 | ENSP00000353270 | ENSP00000349970 | ERGIC and golgi 2; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) | ERGIC and golgi 3; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) | 0.961 |
ERGIC2 | ERO1L | ENSP00000353270 | ENSP00000379042 | ERGIC and golgi 2; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) | ERO1-like (S. cerevisiae); Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of g [...] | 0.710 |
ERGIC2 | ERO1LB | ENSP00000353270 | ENSP00000346635 | ERGIC and golgi 2; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) | ERO1-like beta (S. cerevisiae); Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently [...] | 0.710 |
ERGIC2 | GANAB | ENSP00000353270 | ENSP00000340466 | ERGIC and golgi 2; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) | glucosidase, alpha; neutral AB; Cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins | 0.773 |
ERGIC2 | GANC | ENSP00000353270 | ENSP00000326227 | ERGIC and golgi 2; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) | glucosidase, alpha; neutral C; Has alpha-glucosidase activity | 0.773 |
ERGIC2 | SEL1L | ENSP00000353270 | ENSP00000337053 | ERGIC and golgi 2; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) | sel-1 suppressor of lin-12-like (C. elegans); May play a role in Notch signaling (By similarity). May be involved in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins | 0.830 |
ERGIC2 | SEL1L2 | ENSP00000353270 | ENSP00000284951 | ERGIC and golgi 2; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) | sel-1 suppressor of lin-12-like 2 (C. elegans) | 0.830 |
ERGIC2 | SURF4 | ENSP00000353270 | ENSP00000361057 | ERGIC and golgi 2; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) | surfeit 4; May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi | 0.764 |
ERGIC2 | UBC | ENSP00000353270 | ENSP00000344818 | ERGIC and golgi 2; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) | ubiquitin C | 0.850 |
ERGIC3 | COPB1 | ENSP00000349970 | ENSP00000249923 | ERGIC and golgi 3; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) | coatomer protein complex, subunit beta 1; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; th [...] | 0.439 |
ERGIC3 | ERGIC2 | ENSP00000349970 | ENSP00000353270 | ERGIC and golgi 3; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) | ERGIC and golgi 2; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) | 0.961 |
ERGIC3 | ERO1L | ENSP00000349970 | ENSP00000379042 | ERGIC and golgi 3; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) | ERO1-like (S. cerevisiae); Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of g [...] | 0.758 |
ERGIC3 | ERO1LB | ENSP00000349970 | ENSP00000346635 | ERGIC and golgi 3; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) | ERO1-like beta (S. cerevisiae); Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently [...] | 0.758 |
ERGIC3 | GANAB | ENSP00000349970 | ENSP00000340466 | ERGIC and golgi 3; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) | glucosidase, alpha; neutral AB; Cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins | 0.410 |
ERGIC3 | GANC | ENSP00000349970 | ENSP00000326227 | ERGIC and golgi 3; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) | glucosidase, alpha; neutral C; Has alpha-glucosidase activity | 0.410 |
ERGIC3 | SURF4 | ENSP00000349970 | ENSP00000361057 | ERGIC and golgi 3; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) | surfeit 4; May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi | 0.626 |